Effect of metoclopramide, bethanechol and the cholecystokinin receptor antagonist, L-364,718, on gastric emptying in the rat
| Autor: | Elnitsky At, McDowell Ap, Pendleton Rg, Jenkins Am, Decktor Dl |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Metoclopramide Bethanechol Devazepide Cholecystokinin receptor Bethanechol Compounds Internal medicine medicine Animals Cholecystokinin Pharmacology Benzodiazepinones Meal Gastric emptying business.industry digestive oral and skin physiology Antagonist Rats Inbred Strains Test agent Rats Endocrinology Gastric Emptying Receptors Cholecystokinin business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 147:313-316 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(88)90795-9 |
| Popis: | The prokinetic effects of metociopramide, beihanechol and L-364,718 on a semisolid meal and solid pellet gastric emptying were evaluated and compared. Each compound increased the rate of meal emptying as measured 90 min post-dose, L-364,718, a non-peptide CCK antagonist, was the most potent of these three agents with statistically significant activity observed at 0.03, 0.1 and 0.3 mg/kg p.o. Only metoclopramide significantly enhanced emptying in a dose-dependent manner (3–30 mg/kg p.o.). The effects of each test agent and the potential physiologic role of cholecystokinin in regulating gastric emptying are discussed. |
| Databáze: | OpenAIRE |
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