A Novel Human Prostate-Specific, Androgen-Regulated Homeobox Gene (NKX3.1) That Maps to 8p21, a Region Frequently Deleted in Prostate Cancer
| Autor: | Meena Augustus, P J Sciavolino, Wei Wu He, Brenda K. Shell, Kenneth C. Carter, D J Tindall, Cory Abate-Shen, P S Meissner, J Wing, D G Bostwick, P Hudson, R T Curtis, Edward P. Gelmann |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male PCA3 medicine.medical_specialty Neoplasms Hormone-Dependent medicine.drug_class Molecular Sequence Data Genes Insect Biology urologic and male genital diseases Loss of heterozygosity Mice Prostate cancer Prostate Internal medicine LNCaP Tumor Cells Cultured Genetics medicine Animals Humans Tissue Distribution Amino Acid Sequence RNA Messenger Cloning Molecular In Situ Hybridization Fluorescence Homeodomain Proteins Base Sequence Genes Homeobox Chromosome Mapping Prostatic Neoplasms DNA Chromoplexy Androgen medicine.disease medicine.anatomical_structure Endocrinology Gene Expression Regulation Tumor progression Androgens Cancer research Drosophila Chromosome Deletion Chromosomes Human Pair 8 Transcription Factors |
| Zdroj: | Genomics. 43:69-77 |
| ISSN: | 0888-7543 |
| DOI: | 10.1006/geno.1997.4715 |
| Popis: | We have isolated a prostate-specific gene (NKX3.1) in humans that is homologous to the Drosophila NK homeobox gene family. Northern blot analyses indicate that this gene is expressed at high levels in adult prostate and at a much lower level in testis, but is expressed little or not at all in several other tissues. In an androgen-dependent prostate carcinoma line, LNCaP, NKX3.1 mRNA is expressed at a basal level that was increased markedly upon androgen stimulation; the NKX3.1 mRNA was undetectable in several other human tumor cell lines including two androgen-independent prostate carcinoma lines. The NKX3.1 gene maps to chromosome band 8p21, a region frequently reported to undergo a loss of heterozygosity associated with tissue dedifferentiation and loss of androgen responsiveness during the progression of prostate cancer. Based on these data we propose that NKX3.1 is a candidate gene for playing a role in the opposing processes of androgen-driven differentiation of prostatic tissue and loss of that differentiation during the progression of prostate cancer. |
| Databáze: | OpenAIRE |
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