Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells
| Autor: | YūF. Sasaki, Toshihiro Ohta, Yasuhiko Shirasu, Hisako Imanishi |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Hamster
Sister chromatid exchange Toxicology Umbelliferone Chinese hamster Cell Line Structure-Activity Relationship chemistry.chemical_compound Cricetulus Cricetinae Genetics Animals Ethylvanillin Drug Interactions biology Chinese hamster ovary cell Vanillin Ovary Fibroblasts biology.organism_classification Flavoring Agents chemistry Biochemistry Benzaldehydes Mutation Female Sister Chromatid Exchange Antimutagen Mutagens |
| Zdroj: | Mutation Research/Genetic Toxicology. 189:313-318 |
| ISSN: | 0165-1218 |
| DOI: | 10.1016/0165-1218(87)90063-2 |
| Popis: | Effects of antimutagenic flavourings such as vanillin, ethylvanillin, anisaldehyde, cinnamaldehyde, coumarin and umbelliferone on the induction of SCEs by MMC were investigated in cultured Chinese hamster ovary cells. None of these 6 flavourings showed any SCE-inducing activity by themselves. However, an obvious increase in the frequencies of SCEs was observed when MMC-pretreated cells were cultured in the presence of each flavouring. All these compounds have either an α, β-unsaturated carbonyl group or a carbonyl functionality neighbouring the phenyl group which may react with an enzyme SH-group and cause higher-order structure changes. SCE-enhancing effects of vanillin were further investigated on 6 other kinds of mutagens. Vanillin was also effective on SCEs induced by EMS, ENNG, ENU or MNU. On the other hand, MMS- or MNNG-induced SCEs were not influenced at all by vanillin. SCE-enhancing effects of vanillin seemed to be dependent on the quality of lesions in DNA. |
| Databáze: | OpenAIRE |
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