Markedly Increasing Antibiotic Resistance and Dual Treatment of Neisseria gonorrhoeae Isolates in Guangdong, China, from 2013 to 2020
| Autor: | Xiaomian Lin, Xiaolin Qin, Xingzhong Wu, Yiwen Liao, Yuqi Yu, Qinghui Xie, Sanmei Tang, Chixing Guo, Junming Pei, Zhizhou Wu, Changhui Cai, Feng Wang, Shanghua Wu, Heyong Chen, Xiaofeng Liu, Ming Li, Wenling Cao, Heping Zheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
China Cephalosporin Resistance Ceftriaxone Microbial Sensitivity Tests Azithromycin Neisseria gonorrhoeae Epidemiology and Surveillance Anti-Bacterial Agents Cephalosporins Gonorrhea Infectious Diseases Cefixime Drug Resistance Bacterial Humans Pharmacology (medical) Multilocus Sequence Typing |
| Zdroj: | Antimicrob Agents Chemother |
| Popis: | The emergence of multidrug resistance in Neisseria gonorrhoeae is concerning, especially the cooccurrence of azithromycin resistance and decreased susceptibility to extended-spectrum cephalosporin. This study aimed to confirm the antibiotic resistance trends and provide a solution for N. gonorrhoeae treatment in Guangdong, China. A total of 5,808 strains were collected for assessment of antibiotic MICs. High resistance to penicillin (53.80 to 82%), tetracycline (88.30 to 100%), ciprofloxacin (96 to 99.8%), cefixime (6.81 to 46%), and azithromycin (8.60 to 20.03%) was observed. Remarkably, spectinomycin and ceftriaxone seemed to be the effective choices, with resistance rates of 0 to 7.63% and 2.00 to 16.18%, respectively. Moreover, the rates of azithromycin resistance combined with decreased susceptibility to ceftriaxone and cefixime reached 9.28% and 8.64%, respectively. Furthermore, genotyping identified NG-STAR-ST501, NG-MAST-ST2268, and MLST-ST7363 as the sequence types among representative multidrug-resistant isolates. Evolutionary analysis showed that FC428-related clones have spread to Guangdong, China, which might be a cause of the rapid increase in extended-spectrum cephalosporin resistance currently. Among these strains, the prevalence of N. gonorrhoeae was extremely high, and single-dose ceftriaxone treatment might be a challenge in the future. To partially relieve the treatment pressure, a susceptibility test for susceptibility to azithromycin plus extended-spectrum cephalosporin dual therapy was performed. The results showed that all the representative isolates could be effectively killed with the coadministration of less than 1 mg/liter azithromycin and 0.125 mg/liter extended-spectrum cephalosporin, with a synergistic effect according to a fractional inhibitory concentration (FIC) of |
| Databáze: | OpenAIRE |
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