Analysis of Drosophila melanogaster Lifespan
| Autor: | Gary N. Landis, Devon V. Doherty, John Tower |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetics Aging biology Longevity fungi biology.organism_classification Article Diet 03 medical and health sciences Drosophila melanogaster 030104 developmental biology 0302 clinical medicine Biomarkers of aging Animals Drosophila Biomarkers 030217 neurology & neurosurgery Caloric Restriction |
| Zdroj: | Aging ISBN: 9781071605912 Methods Mol Biol |
| DOI: | 10.1007/978-1-0716-0592-9_4 |
| Popis: | The laboratory fruit fly Drosophila melanogaster is one of the leading models for the study of aging. Whereas several behavioral and physiological biomarkers of aging have been identified for Drosophila, life span remains the most robust measure of aging rate. Aging and life span can be modulated by genetic alterations, as well as by drugs and dietary components, to reveal basic and conserved mechanisms of aging. Here methods are presented for Drosophila life span assay, including media preparation, supplementation of media with various drugs, culturing of the flies, passaging flies and recording deaths, and the analysis of life span data. |
| Databáze: | OpenAIRE |
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