The effect of two different types of stress on locus coeruleus alpha-2 receptor binding
| Autor: | Albert Ratner, Daniel D. Savage, Gerald K. Weiss, Natalie Castillo, Anna Voltura, Kristen Lucero |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Dioxanes Rats Sprague-Dawley Norepinephrine Idazoxan Stress Physiological Internal medicine Receptors Adrenergic alpha-1 medicine Animals Receptor Adrenergic alpha-Antagonists Chemistry General Neuroscience Receptor antagonist Rats Cold Temperature Endocrinology Autoreceptor Catecholamine Locus coeruleus Alpha-2 adrenergic receptor Locus Coeruleus medicine.drug |
| Zdroj: | Brain research bulletin. 33(2) |
| ISSN: | 0361-9230 |
| Popis: | The central noradrenergic neurons of the locus coeruleus (LC) are important in regulating an animal's response to a stressor. Changes in alpha-2 autoreceptors on LC neurons during stress could alter the functional state of the LC. We investigated the changes in binding of LC alpha-2 receptors immediately following 1 h and 4 h of two stressors: novelty + cold and prone restraint. We measured the specific binding of the alpha-2 receptor antagonist [3H]idazoxan in the LC of rats using in vitro autoradiography. Specific binding was increased after 1 h of novelty + cold exposure but decreased after 4 h, and after both 1 and 4 h of prone restraint. The increase after 1 h of stress may be due to the ability of LC neurons to regulate their own activity because this would produce a dampening of the high LC activity produced by the stressor. However, extended time and/or intensity of a stressor may overwhelm this initial response and produce an agonist-induced decrease in receptor binding. |
| Databáze: | OpenAIRE |
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