Effects of Delta-9-Tetrahydrocannabinol on the Hypothalamic-Pituitary Control of Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in Adult Male Rats
| Autor: | S. Dalterio, G.D. Snyder, Valeria Rettori, Tibor Wenger, Samuel M. McCann |
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| Rok vydání: | 1987 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Pituitary gland Endocrinology Diabetes and Metabolism Hypothalamus Peptide hormone Biology Gonadotropin-Releasing Hormone Cellular and Molecular Neuroscience Endocrinology Anterior pituitary Pituitary Gland Anterior Internal medicine mental disorders Delta-9-tetrahydrocannabinol medicine Animals Dronabinol Cells Cultured Injections Intraventricular Lamina terminalis Endocrine and Autonomic Systems organic chemicals Follicle-stimulating hormone secretion Rats Inbred Strains Luteinizing Hormone Rats medicine.anatomical_structure Follicle Stimulating Hormone Luteinizing hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroendocrinology. 46:488-493 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000124870 |
| Popis: | The main psychoactive component of marihuana, delta-9-tetrahydrocannabinol (THC) was injected into the 3rd cerebral ventricle. A single dose of THC (2 microliter of 10(-6) M) decreased serum LH temporarily but did not alter serum follicle-stimulating hormone (FSH) levels. The mediobasal hypothalamic (MBH) luteinizing hormone-releasing hormone (LHRH) content was elevated by 30 min after the injection. The elevation persisted for 1 h. Then, the LHRH content returned towards the preinjection level. In contrast, the LHRH in the organum vasculosum of the lamina terminalis did not change after a single dose of THC. The results indicate that THC alters pituitary LH release by inhibiting the release of LHRH which then increases in the MBH by continued synthesis or transport from rostral areas. In addition, the data support the existence of an FSH releasing factor, the release of which is not suppressed by this dose of THC. THC did not alter the release, storage or responsiveness to LHRH of cultured anterior pituitary cells, which further supports the view that its principal site of action is on the hypothalamus. |
| Databáze: | OpenAIRE |
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