Antiproliferative effect of intravitreal a-tocopherol and a-tocopheryl-acid-succinate in a rabbit model of PVR
| Autor: | Miguel F. Refojo, Jose M. Larrosa, Fee-Lai Leong, Amadeo A.S. Veloso |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Proliferative vitreoretinopathy
medicine.medical_specialty medicine.medical_treatment Tocopherols Balanced salt solution Vitrectomy Cellular and Molecular Neuroscience chemistry.chemical_compound medicine Animals Silicone Oils Vitamin E Saline Chromatography Ethanol Chemistry Vitreoretinopathy Proliferative Retinal Detachment medicine.disease Sensory Systems Silicone oil Vitreous Body Disease Models Animal Ophthalmology Anesthesia Histopathology Rabbits alpha-Tocopherol Cell Division |
| Zdroj: | Current Eye Research. 16:1030-1035 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.1076/ceyr.16.10.1030.9022 |
| Popis: | To evaluate the antiproliferative properties of alpha-tocopherol and alpha-tocopheryl-acid-succinate in a rabbit model of proliferative vitreoretinopathy.Fifty-seven rabbits underwent gas-compression vitrectomy and gas/fluid exchange. Group 1 (n = 8): 50 micrograms alpha-tocopherol in 1 ml of 0.5% ethanol in balanced salt solution; Group 2 (n = 8): 50 micrograms alpha-tocopheryl-acid-succinate in 1 ml of 0.5% ethanol in balanced salt solution; Groups 3 (n = 4) and 4 (n = 2): 1 ml 0.5% ethanol in balanced salt solution; Groups 5 (n = 12) and 8 (n = 9): alpha-tocopherol in 1 ml silicone oil (12 mg/ml); Group 6 (n = 9): 1 ml silicone oil; Group 7 (n = 5): 1 ml balanced salt solution. Groups 1-3, and 5-7 also received fibroblasts and platelet-rich plasma injection. Fundus evaluation was performed during a four-week period. The eyes were enucleated for gross examination on day 28. Histopathology was performed on Group 4.Alpha-tocopherol and alpha-tocopheryl-acid-succinate in saline solution delayed development of proliferative vitreoretinopathy, compared to the control group (statistically significant during the first week, Mann Whitney, p0.05). The alpha-tocopherol in the silicone-oil group delayed development of proliferative vitreoretinopathy, compared to the silicone-oil group during the second to fourth weeks (no statistically significant difference, p0.05).Alpha-tocopherol and alpha-tocopheryl-acid-succinate in saline solution showed retardation of proliferative vitreoretinopathy traction retinal detachments. In silicone oil, alpha-tocopherol is slowly released and decreases the severity of proliferative vitreoretinopathy, especially during the second week of follow-up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|