Ultrasensitivity and Positive Feedback to Promote Sharp Mitotic Entry

Autor:	Youlian Goulev, Gilles Charvin
Rok vydání:	2011
Předmět:	Kinase Cyclin-dependent kinase Ultrasensitivity biology.protein Phosphorylation Cell Biology Biology Molecular Biology Mitosis Cell biology Positive feedback
Zdroj:	Molecular Cell. 41:243-244
ISSN:	1097-2765
DOI:	10.1016/j.molcel.2011.01.016
Popis:	In this issue, Trunnell et al. (2011) show that in mitotic entry the positive feedback that drives the activation of cyclin-dependent kinase (Cdk) involves a very ultrasensitive step of phosphorylation of Cdc25C by Cdk, thus strongly contributing to the switch-like behavior of this essential cell-cycle transition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51552380af2ed4270f3c50e7d5922b1 https://doi.org/10.1016/j.molcel.2011.01.016 Zobrazit plný text záznamu