Cognitive functioning one month and one year following febrile status epilepticus
| Autor: | Shlomo Shinnar, Veronica J. Hinton, Ruth C. Shinnar, Douglas R. Nordli, Dale C. Hesdorffer, William Gallentine, David Masur, Shumei Sun, Julie Rinaldi, Leon G. Epstein, Syndi Seinfeld, Virginia Van de Water, Solomon L. Moshé, Melanie J. Bonner, James Culbert, L. Mathew Frank, Erica F. Weiss |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neuroimaging Status epilepticus Neuropsychological Tests Hippocampus Article Seizures Febrile 03 medical and health sciences Behavioral Neuroscience Epilepsy Cognition Status Epilepticus 0302 clinical medicine Memory 030225 pediatrics Febrile seizure medicine Humans Cognitive skill Motor skill Language Infant medicine.disease Magnetic Resonance Imaging Neurology Child Preschool Cohort Female Neurology (clinical) medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy & Behavior. 64:283-288 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2016.09.013 |
| Popis: | Objective The objective of this study was to determine early developmental and cognitive outcomes of children with febrile status epilepticus (FSE) one month and one year after FSE. Methods One hundred ninety four children with FSE were evaluated on measures of cognition, receptive language, and memory as part of the FEBSTAT study and compared with 100 controls with simple febrile seizures (FSs). Results Children with FSE did not differ dramatically on tasks compared with FS controls at one month after FSE but demonstrated slightly weaker motor development (p = 0.035) and receptive language (p = 0.034) at one year after FSE. Performances were generally within the low average to average range. Within the FSE cohort, non-White children performed weaker on many of the tasks compared with Caucasian children. At the one-year visit, acute hippocampal T2 findings on MRI were associated with weaker receptive language skills (p = 0.0009), and human herpes virus 6 or 7 (HHV6/7) viremia was associated with better memory performances (p = 0.047). Conclusion Febrile status epilepticus does not appear to be associated with significant cognitive impairment on early developmental measures, although there is a trend for possible receptive language and motor delay one year after FSE. Further follow-up, which is in progress, is necessary to track long-term cognitive functioning. |
| Databáze: | OpenAIRE |
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