Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety
| Autor: | Nuray Ulusoy Güzeldemirci, Ömer Küçükbasmacı |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Chemistry Stereochemistry Organic Chemistry Fungi 1 2 4-Triazole Microbial Sensitivity Tests Mycobacterium tuberculosis General Medicine Triazoles Hydrazide Antimicrobial Chemical synthesis chemistry.chemical_compound Anti-Infective Agents Xanthenes Thiadiazoles Oxazines Drug Discovery Radiometry Antibacterial activity Thiazole Antibacterial agent |
| Zdroj: | European Journal of Medicinal Chemistry. 45:63-68 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2009.09.024 |
| Popis: | A series of 4-alkyl/aryl-2,4-dihydro-5-((6-(4-bromophenyl)imidazo[2,1- b ]thiazol-3-yl)methyl)-3 H -1,2,4-triazole-3-thiones ( 3a – i ) and 2-alkyl/arylamino-5-((6-(4-bromophenyl)imidazo[2,1- b ]thiazol-3-yl)methyl)-1,3,4-thiadiazoles ( 4a – c ) were synthesized starting from 6-(4-bromophenyl)imidazo[2,1- b ]thiazole-3-acetic acid hydrazide. The newly synthesized compounds were characterized by IR, 1 H NMR, mass and elemental analysis. All compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H 37 Rv (ATCC 27294). The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities. |
| Databáze: | OpenAIRE |
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