Evaluation of the antidepressant- and anxiolytic-like effects of a hydrophilic extract from the green seaweed Ulva sp. in rats
| Autor: | Hervé Demais, Pascale Rozan, Pi Nyvall Collén, Jean-François Bisson, Nicolas Violle |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Elevated plus maze Imipramine Medicine (miscellaneous) Biology Pharmacology Anxiolytic like Toxicology 03 medical and health sciences Ulva 0302 clinical medicine parasitic diseases medicine Toxicity Tests Acute Animals Rats Wistar Swimming Nutrition and Dietetics Behavior Animal Dose-Response Relationship Drug Plant Extracts General Neuroscience Toxicity Tests Subchronic General Medicine Acute toxicity Antidepressive Agents Subchronic toxicity Rats 030104 developmental biology Anti-Anxiety Agents Sulphated polysaccharides Exploratory Behavior Antidepressant Female 030217 neurology & neurosurgery medicine.drug Behavioural despair test |
| Zdroj: | Nutritional neuroscience. 21(4) |
| ISSN: | 1476-8305 |
| Popis: | The green seaweed Ulva sp. contains a large amount of ulvans, a family of sulphated polysaccharides. The present study was designed to investigate in rats the antidepressant- and anxiolytic-like effects of a hydrophilic extract of Ulva sp. (MSP) containing about 45% of ulvans.After a 14-day administration of MSP at doses of 10, 20 and 40 mg/kg/day, 48 and 60 male adult Wistar rats were respectively tested in the elevated plus-maze (EPM) and the forced swimming test (FST). In the FST, MSP effects were compared to the reference antidepressant drug imipramine (IMI) (10 mg/kg/day). Acute and sub-chronic toxicities of the extract were also assessed in male and female rats following OECD guidelines.MSP treatment did not modify anxiety-related behaviour in the EPM. In contrast, MSP induced a dose-dependent reduction of immobility behaviour in the FST. At the highest tested dose of 40 mg/kg, MSP displayed a significant antidepressant-like effect similar to IMI. MSP did not modify the exploratory behaviour of rats in the open field test and did not produce any toxic effect.MSP may potentially represent a good adjunct or alternative to existing antidepressant therapeutics. Further studies are necessary to confirm the mechanism of action of MSP and its modulation of brain functioning. |
| Databáze: | OpenAIRE |
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