Patterns of acute vascular injury after intra-arterial barbiturate injection
| Autor: | Harrison M. Lazarus, Richard Auerbach, David Ellertson |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Spasm
Necrosis Thrombophlebitis Veins Gangrene medicine Animals Ear External Thiopental Thiopental Sodium business.industry Thrombosis General Medicine Arteries medicine.disease Pathophysiology Arterial tree Radiography Venous thrombosis Contrast medium medicine.anatomical_structure Venous Insufficiency Anesthesia Anesthesia Intravenous Blood Vessels Surgery Rabbits medicine.symptom business Artery |
| Zdroj: | American journal of surgery. 126(6) |
| ISSN: | 0002-9610 |
| Popis: | Summary The rabbit ear was employed to study angiographic alterations induced by intra-arterial injection of thiopental sodium. Acute venoconstriction was the first angiographic abnormality detected, occurring fifteen minutes after Pentothal injection. One hour after injection, progressive venospasm and segmental thromboses were apparent; arterial spasm was minimal. Twenty-four hours after injection, segmental venous thrombosis was prominent. The arterial tree remained patent; however, artery wall irregularities suggested nonocclusive mural thromboses or intimal injury. Seventy-two hours after intra-arterial injection of thiopental sodium, well demarcated gangrene was evident and correlated with extravasated contrast medium. Angiograms demonstrated variable patency of the arterial tree. This study emphasizes the possible role of acute venous injury in the pathogenesis of intra-arterial barbiturate-induced necrosis. A pathophysiologic sequence that correlates our findings with previous experimental efforts by others is presented. |
| Databáze: | OpenAIRE |
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