Long‐Term Prognosis of Brugada‐Type ECG and ECG With Atypical ST‐Segment Elevation in the Right Precordial Leads Over 20 Years: Results From the Circulatory Risk in Communities Study (CIRCS)
| Autor: | Masayuki Yao, Tetsuya Ohira, Hideki Ozawa, Akihiko Kitamura, Yoshio Komachi, Hiroyuki Noda, Isao Muraki, Yoko Ito, Shinichi Sato, Satoyo Ikehara, Takeshi Tanigawa, Tomoko Sankai, Keisuke Kuga, Yoshihiko Naito, Takashi Shimamoto, Susumu Sakurai, Dongzhu Xu, Yuji Shimizu, Hiroshi Tada, Shinichi Hitsumoto, Hiro Yamasaki, Masakazu Nakamura, Kazutaka Aonuma, Yoshinori Ishikawa, Minoru Iida, Yukio Sekiguchi, Miyako Igarashi, Hidekazu Tsuneoka, Yoshihisa Naruse, Takeo Okada, Mitsumasa Umesawa, Hiroyasu Iso, Minako Tabata, Isao Saito, Masahiko Takagi, Nobuyuki Murakoshi, Choy-Lye Chei, Masatoshi Ido, Hironori Imano, Kazumasa Yamagishi, Ai Ikeda, Yasuhiro Yokoyama, Masahiko Kiyama, Kimiko Yokota, Renzhe Cui, Kenji Maeda, Masamitsu Konishi |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidemiology electrocardiography Population 030204 cardiovascular system & hematology sudden cardiac death Sudden cardiac death 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Ross River virus Humans Medicine ST segment Brugada syndrome 030212 general & internal medicine education Original Research education.field_of_study medicine.diagnostic_test business.industry fungi Hazard ratio Middle Aged Prognosis medicine.disease Death Sudden Cardiac Cardiology ST Elevation Myocardial Infarction Female Cardiology and Cardiovascular Medicine business Electrocardiography Cohort study |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background Brugada syndrome is recognized as being associated with sudden cardiac death; however, the prevalence of non–type 1 Brugada‐type ECG (BrS) or atypical ST ‐segment elevation in the right precordial leads ( STERP ) and the long‐term prognosis for those patients remain unknown. Methods and Results We analyzed standard 12‐lead ECG s of 7178 apparently healthy participants (age range 40–64 years) who underwent health checkups from 1982 to 1986 in the Circulatory Risk in Communities Study, a prospective, large, community‐based cohort study in Japan. ECG s with J point amplitude ≥0.2 mV in the right precordial leads were divided into 3 groups: (1) type 1 BrS, (2) type 2 or 3 BrS (non‐type 1 BrS), and (3) STERP . The others served as the non– ST ‐segment elevation group. We identified 8 participants (0.1%) with type1 BrS, 84 (1.2%) with non–type 1 BrS, and 228 (3.2%) with STERP . During a median follow‐up of 18.7 years (133 987.0 person‐years), sudden cardiac death was observed in no participants (0.0%) with type 1 BrS, in 1 (1.2%) with non–type 1 BrS, in 7 (3.1%) with STERP , and in 50 (0.7%) with non– ST ‐segment elevation. Participants with STERP had a markedly elevated risk of sudden cardiac death (multivariable hazard ratio 3.9, 95% CI 1.7–9.0). Conclusions STERP was associated with an elevated risk of sudden cardiac death in a middle‐aged population. |
| Databáze: | OpenAIRE |
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