| Autor: |
Seng Cheong, Loke, Ravindran, Kanesvaran, Rosnawati, Yahya, Liza, Fisal, Teck Wee, Wong, Yik Yee, Loong |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Annals of the Academy of Medicine, Singapore. 38:1074-1080 |
| ISSN: |
0304-4602 |
| DOI: |
10.47102/annals-acadmedsg.v38n12p1074 |
| Popis: |
Introduction: Intravenous calcium gluconate has been used to prevent postoperative hypo-calcaemia (POH) following parathyroidectomy for secondary hyperparathyroidism in chronic kidney disease (CKD). Materials and Methods: Retrospective data were obtained for 36 patients with CKD stage 4 and 5 after parathyroid surgery, correlating albumin-corrected serum calcium with the infusion rate of calcium gluconate. Calcium flux was characterised along with excursions out of the target calcium range of 2 to 3 mmol/L. With this data, an improved titration regimen was constructed. Results: Mean peak efflux rate (PER) from the extracellular calcium pool was 2.97 mmol/h occurring 26.6 hours postoperatively. Peak calcium efflux tended to occur later in cases of severe POH. Eighty-one per cent of patients had excursions outside of the target cal-cium range of 2 to 3 mmol/L. Mean time of onset for hypocalcaemia was 2 days postoperatively. Hypocalcaemia was transient in 25% and persistent in 11% of patients. Conclusion: A simple titration regimen was constructed in which a 10% calcium gluconate infusion was started at 4.5 mL/h when serum calcium was |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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