Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit

Autor: Sakr Y., Rubatto Birri P. N., Kotfis K., Nanchal R., Shah B., Kluge S., Schroeder M. E., Marshall J. C., Vincent J. -L, E Tomas, E Amisi Bibonge, B Charra, M Faroudy, L Doedens, Z Farina, D Adler, C Balkema, A Kok, S Alaya, H Gharsallah, D Muzha, A Temelkov, G Georgiev, G Simeonov, G Tsaryanski, S Georgiev, A Seliman, S Vrankovic, Z Vucicevic, I Gornik, B Barsic, I Husedzinovic, P Pavlik, J Manak, E Kieslichova, R Turek, M Fischer, R Valkova, L Dadak, P Dostal, J Malaska, R Hajek, A Židková, P Lavicka, J Starkopf, Z Kheladze, M Chkhaidze, V Kaloiani, L Medve, A Sarkany, I Kremer, Z Marjanek, P Tamasi, I Krupnova, I Vanags, V Liguts, V Pilvinis, S Vosylius, G Kekstas, M Balciunas, J Kolbusz, A Kübler, B Mielczarek, M Mikaszewska-Sokolewicz, K Kotfis, B Tamowicz, W Sulkowski, P Smuszkiewicz, A Pihowicz, E Trejnowska, N Hagau, D Filipescu, G Droc, M Lupu, A Nica, R Stoica, D Tomescu, D Constantinescu, G Valcoreanu Zbaganu, A Slavcovici, V Bagin, D Belsky, S Palyutin, S Shlyapnikov, D Bikkulova, A Gritsan, G Natalia, E Makarenko, V Kokhno, A Tolkach, E Kokarev, B Belotserkovskiy, K Zolotukhin, V Kulabukhov, L Soskic, I Palibrk, R Jankovic, B Jovanovic, M Pandurovic, V Bumbasirevic, B Uljarevic, M Surbatovic, N Ladjevic, G Slobodianiuk, V Sobona, A Cikova, A Gebhardtova, C Jun, S Yunbo, J Dong, S Feng, M Duan, Y Xu, X Xue, T Gao, X Xing, X Zhao, C Li, G Gengxihua, H Tan, J Xu, L Jiang, Q Tiehe, Q Bingyu, Q Shi, Z Lv, L Zhang, L Jingtao, Z Zhen, Z Wang, T Wang, L Yuhong, Q Zhai, Y Chen, C Wang, W Jiang, W Ruilan, Y Chenv, H Xiaobo, H Ge, T Yan, C Yuhui, J Zhang, F Jian-Hong, H Zhu, F Huo, Y Wang, M Zhuang, Z Ma, J Sun, L Liuqingyue, M Yang, J Meng, S Ma, Y Kang, L Yu, Q Peng, Y Wei, W Zhang, R Sun, A Yeung, W Wan, K Sin, K Lee, M Wijanti, U Widodo, H Samsirun, T Sugiman, C Wisudarti, T Maskoen, N Hata, Y Kobe, O Nishida, D Miyazaki, S Nunomiya, S Uchino, N Kitamura, K Yamashita, S Hashimoto, H Fukushima, N Nik Adib, L Tai, B Tony, R Bigornia, J Palo, S Chatterjee, B Tan, A Kong, S Goh, C Lee, C Pothirat, B Khwannimit, P Theerawit, P Pornsuriyasak, A Piriyapatsom, A Mukhtar, A Nabil Hamdy, H Hosny, A Ashraf, M Mokhtari, S Nowruzinia, A Lotfi, F Zand, R Nikandish, O Moradi Moghaddam, J Cohen, O Sold, T Sfeir, A Hasan, D Abugaber, H Ahmad, T Tantawy, S Baharoom, H Algethamy, A Amr, G Almekhlafi, R Coskun, M Sungur, A Cosar, B Güçyetmez, O Demirkiran, E Senturk, H Ulusoy, H Atalan, S Serin, I Kati, Z Alnassrawi, A Almemari, K Krishnareddy, S Kashef, A Alsabbah, G Poirier, J Marshall, M Herridge, R Fernandez-Medero, G Fulda, S Banschbach, J Quintero, E Schroeder, C Sicoutris, R Gueret, R Kashyap, P Bauer, R Nanchal, R Wunderink, E Jimenez, A Ryan, D Prince, J Edington, F Van Haren, A Bersten, D J Hawkins, M Kilminster, D Sturgess, M Ziegenfuss, S O' Connor, J Lipman, L Campbell, R Mcallister, B Roberts, P Williams, R Parke, P Seigne, R Freebairn, D Nistor, C Oxley, P Young, R Valentini, N Wainsztein, P Comignani, M Casaretto, G Sutton, P Villegas, C Galletti, J Neira, D Rovira, J Hidalgo, F Sandi, E Caser, M Thompson, M D'agostino Dias, L Fontes, M Lunardi, N Youssef, S Lobo, R Silva, J Sales Jr, L Madeira Campos Melo, M Oliveira, M Fonte, C Grion, C Feijo, V Rezende, M Assuncao, A Neves, P Gusman, D Dalcomune, C Teixeira, K Kaefer, I Maia, V Souza Dantas, R Costa Filho, F Amorim, M Assef, P Schiavetto, J Houly, F Bianchi, F Dias, C Avila, J Gomez, L Rego, P Castro, J Passos, C Mendes, G Colozza Mecatti, M Ferrreira, V Irineu, M Guerreiro, S Ugarte, V Tomicic, C Godoy, W Samaniego, I Escamilla, L Castro Castro, G Libreros Duque, D Diaz-Guio, F Benítez, A Guerra Urrego, R Buitrago, G Ortiz, M Villalba Gaviria, D Salas, J Ramirez-Arce, E Salgado, D Morocho, J Vergara, M Chung Sang, C Orellana-Jimenez, L Garrido, O Diaz, D Resiere, C Osorio, A De La Vega, R Carrillo, V Sanchez, A Villagomez, R Martinez Zubieta, M Sandia, M Zalatiel, M Poblano, D Rodriguez Gonzalez, F Arrazola, L Juan Francisco, S A Ñamendys-Silva, M Hernandez, D Rodriguez Cadena, I Lopez Islas, C Ballesteros Zarzavilla, A Matos, I Oyanguren, J Cerna, R Quispe Sierra, R Jimenez, L Castillo, R Ocal, A Sencan, S Mareque Gianoni, A Deicas, J Hurtado, G Burghi, A Martinelli, I Von Der Osten, C Du Maine, M Bhattacharyya, S Bandyopadhyay, S Yanamala, P Gopal, S Sahu, M Ibrahim, D Rathod, N Mukundan, A Dewan, P Amin, S Samavedam, B Shah, D Gurupal, B Lahkar, A Mandal, M Sircar, S Ghosh, V Balasubramani, F Kapadia, S Vadi, K Nair, S Tripathy, S Nandakumar, J Sharma, A Kar, S Jha, K Zirpe-Gurav, M Patel, A Bhavsar, D Samaddar, A Kulkarni, M Hashmi, W Ali, S Nadeem, K Indraratna, A Margarit, P Urbanek, J Schlieber, J Reisinger, J Auer, A Hartjes, A Lerche, T Janous, E Kink, W Krahulec, K Smolle, M Van Der Schueren, P Thibo, M Vanhoof, I Ahmet, G Philippe, P Dufaye, O Jacobs, V Fraipont, P Biston, A Dive, Y Bouckaert, E Gilbert, B Gressens, E Pinck, V Collin, J L Vincent, J De Waele, R Rimachi, D Gusu, K De Decker, K Mandianga, L Heytens, X Wittebole, S Herbert, V Olivier, W Vandenheede, P Rogiers, P Kolodzeike, M Kruse, T Andersen, V Harjola, K Saarinen, M Leone, A Durocher, S Moulront, A Lepape, M Losser, P Cabaret, E Kalaitzis, E Zogheib, P Charve, B Francois, J Y Lefrant, B Beilouny, X Forceville, B Misset, F Jacobs, F Bernard, D Payen, A Wynckel, V Castelain, A Faure, P Lavagne, L Thierry, M Moussa, A Vieillard-Baron, M Durand, M Gainnier, C Ichai, S Arens, C Hoffmann, M Kaffarnik, C Scharnofske, I Voigt, C Peckelsen, M Weber, J Gille, A Lange, G Schoser, A Sablotzki, U Jaschinski, A Bluethgen, F Vogel, A Tscheu, T Fuchs, M Wattenberg, T Helmes, S Scieszka, M Heintz, S Sakka, J Kohler, F Fiedler, M Danz, Y Sakr, R Riessen, T Kerz, A Kersten, F Tacke, G Marx, T Volkert, A Schmutz, A Nierhaus, S Kluge, P Abel, R Janosi, S Utzolino, H Bracht, S Toussaint, M Giannakou Peftoulidou, P Myrianthefs, A Armaganidis, C Routsi, A Xini, E Mouloudi, I Kokoris, G Kyriazopoulos, S Vlachos, A Lavrentieva, P Partala, G Nakos, A Moller, S Stefansson, J Barry, R O'Leary, C Motherway, M Faheem, E Dunne, M Donnelly, T Konrad, E Bonora, C Achilli, S Rossi, G Castiglione, A Peris, D Albanese, N Stocchetti, G Citerio, L Mozzoni, E Sisillo, P De Negri, M Savioli, P Vecchiarelli, F Puflea, V Stankovic, G Minoja, S Montibeller, P Calligaro, R Sorrentino, M Feri, M Zambon, E Colombaroli, A Giarratano, T Pellis, C Capra, M Antonelli, A Gullo, C Chelazzi, A De Capraris, N Patroniti, M Girardis, F Franchi, G Berlot, M Buttigieg, H Ponssen, J Ten Cate, L Bormans, S Husada, M Buise, B Van Der Hoven, A Reidinga, M Kuiper, P Pickkers, G Kluge, S Den Boer, J Kesecioglu, H Van Leeuwen, H Flaatten, S Mo, V Branco, F Rua, E Lafuente, M Sousa, N Catorze, M Barros, L Pereira, A Vintém De Oliveira, J Gomes, I Gaspar, M Pereira, M Cymbron, A Dias, E Almeida, S Beirao, I Serra, R Ribeiro, P Povoa, F Faria, Z Costa-E-Silva, J Nóbrega, F Fernandes, J Gabriel, G Voga, E Rupnik, L Kosec, M Kerin Povšic, I Osojnik, V Tomic, A Sinkovic, J González, E Zavala, J Pérez Valenzuela, L Marina, P Vidal-Cortés, P Posada, A Ignacio Martin-Loeches, N Muñoz Guillén, M Palomar, J Sole-Violan, A Torres, M Gonzalez Gallego, G Aguilar, R Montoiro Alluév, M Argüeso, M Parejo, M Palomo Navarro, A Jose, N Nin, F Alvarez Lerma, O Martinez, E Tenza Lozano, S Arenal López, M Perez Granda, S Moreno, C Llubia, C De La Fuente Martos, P Gonzalez-Arenas, N Llamas Fernández, B Gil Rueda, I Estruch Pons, N Cruza, F Maroto, A Estella, A Ferrer, L Iglesias Fraile, B Quindos, A Quintano, M Tebar, P Cardinal, A Reyes, A Rodríguez, A Abella, S García Del Valle, S Yus, E Maseda, J Berezo, A Tejero Pedregosa, C Laplaza, R Ferrer, J Rico-Feijoo, M Rodríguez, P Monedero, K Eriksson, D Lind, D Chabanel, H Zender, K Heer, B Frankenberger, S Jakob, A Haller, S Mathew, R Downes, C Barrera Groba, A Johnston, R Meacher, R Keays, P Haji-Michael, C Tyler, A Ferguson, S Jones, D Tyl, A Ball, J Vogel, M Booth, P Downie, M Watters, S Brett, M Garfield, L Everett, S Heenen, S Dhir, Z Beardow, M Mostert, S Brosnan, N Pinto, S Harris, A Summors, N Andrew, A Rose, R Appelboam, O Davies, E Vickers, B Agarwal, T Szakmany, S Wimbush, I Welters, R Pearse, R Hollands, J Kirk-Bayley, N Fletcher, B Bray, D Brealey
Přispěvatelé: Sakr, Y, Rubatto Birri, P, Kotfis, K, Nanchal, R, Shah, B, Kluge, S, Schroeder, M, Marshall, J, Vincent, J, Citerio, G, Sakr Y., Rubatto Birri P.N., Kotfis K., Nanchal R., Shah B., Kluge S., Schroeder M.E., Marshall J.C., Vincent J.-L, E Tomas, E Amisi Bibonge, B Charra, M Faroudy, L Doedens, Z Farina, D Adler, C Balkema, A Kok, S Alaya, H Gharsallah, D Muzha, A Temelkov, G Georgiev, G Simeonov, G Tsaryanski, S Georgiev, A Seliman, S Vrankovic, Z Vucicevic, I Gornik, B Barsic, I Husedzinovic, P Pavlik, J Manak, E Kieslichova, R Turek, M Fischer, R Valkova, L Dadak, P Dostal, J Malaska, R Hajek, A Židková, P Lavicka, J Starkopf, Z Kheladze, M Chkhaidze, V Kaloiani, L Medve, A Sarkany, I Kremer, Z Marjanek, P Tamasi, I Krupnova, I Vanags, V Liguts, V Pilvinis, S Vosylius, G Kekstas, M Balciunas, J Kolbusz, A Kübler, B Mielczarek, M Mikaszewska-Sokolewicz, K Kotfis, B Tamowicz, W Sulkowski, P Smuszkiewicz, A Pihowicz, E Trejnowska, N Hagau, D Filipescu, G Droc, M Lupu, A Nica, R Stoica, D Tomescu, D Constantinescu, G Valcoreanu Zbaganu, A Slavcovici, V Bagin, D Belsky, S Palyutin, S Shlyapnikov, D Bikkulova, A Gritsan, G Natalia, E Makarenko, V Kokhno, A Tolkach, E Kokarev, B Belotserkovskiy, K Zolotukhin, V Kulabukhov, L Soskic, I Palibrk, R Jankovic, B Jovanovic, M Pandurovic, V Bumbasirevic, B Uljarevic, M Surbatovic, N Ladjevic, G Slobodianiuk, V Sobona, A Cikova, A Gebhardtova, C Jun, S Yunbo, J Dong, S Feng, M Duan, Y Xu, X Xue, T Gao, X Xing, X Zhao, C Li, G Gengxihua, H Tan, J Xu, L Jiang, Q Tiehe, Q Bingyu, Q Shi, Z Lv, L Zhang, L Jingtao, Z Zhen, Z Wang, T Wang, L Yuhong, Q Zhai, Y Chen, C Wang, W Jiang, W Ruilan, Y Chenv, H Xiaobo, H Ge, T Yan, C Yuhui, J Zhang, F Jian-Hong, H Zhu, F Huo, Y Wang, C Li, M Zhuang, Z Ma, J Sun, L Liuqingyue, M Yang, J Meng, S Ma, Y Kang, L Yu, Q Peng, Y Wei, W Zhang, R Sun, A Yeung, W Wan, K Sin, K Lee, M Wijanti, U Widodo, H Samsirun, T Sugiman, C Wisudarti, T Maskoen, N Hata, Y Kobe, O Nishida, D Miyazaki, S Nunomiya, S Uchino, N Kitamura, K Yamashita, S Hashimoto, H Fukushima, N Nik Adib, L Tai, B Tony, R Bigornia, R Bigornia, R Bigornia, J Palo, S Chatterjee, B Tan, A Kong, S Goh, C Lee, C Pothirat, B Khwannimit, P Theerawit, P Pornsuriyasak, A Piriyapatsom, A Mukhtar, A Nabil Hamdy, H Hosny, A Ashraf, M Mokhtari, S Nowruzinia, A Lotfi, F Zand, R Nikandish, O Moradi Moghaddam, J Cohen, O Sold, T Sfeir, A Hasan, D Abugaber, H Ahmad, T Tantawy, S Baharoom, H Algethamy, A Amr, G Almekhlafi, R Coskun, M Sungur, A Cosar, B Güçyetmez, O Demirkiran, E Senturk, H Ulusoy, H Atalan, S Serin, I Kati, Z Alnassrawi, A Almemari, K Krishnareddy, S Kashef, A Alsabbah, G Poirier, J Marshall, M Herridge, M Herridge, R Fernandez-Medero, G Fulda, S Banschbach, J Quintero, E Schroeder, C Sicoutris, R Gueret, R Kashyap, P Bauer, R Nanchal, R Wunderink, E Jimenez, A Ryan, D Prince, J Edington, F Van Haren, A Bersten, D J Hawkins, M Kilminster, D Sturgess, M Ziegenfuss, S O' Connor, J Lipman, L Campbell, R Mcallister, B Roberts, P Williams, R Parke, P Seigne, R Freebairn, D Nistor, C Oxley, P Young, R Valentini, N Wainsztein, P Comignani, M Casaretto, G Sutton, P Villegas, C Galletti, J Neira, D Rovira, J Hidalgo, F Sandi, E Caser, M Thompson, M D'agostino Dias, L Fontes, M Lunardi, N Youssef, S Lobo, R Silva, J Sales Jr, L Madeira Campos Melo, M Oliveira, M Fonte, C Grion, C Feijo, V Rezende, M Assuncao, A Neves, P Gusman, D Dalcomune, C Teixeira, K Kaefer, I Maia, V Souza Dantas, R Costa Filho, F Amorim, M Assef, P Schiavetto, J Houly, F Bianchi, F Dias, C Avila, J Gomez, L Rego, P Castro, J Passos, C Mendes, C Grion, G Colozza Mecatti, M Ferrreira, V Irineu, M Guerreiro, S Ugarte, V Tomicic, C Godoy, W Samaniego, I Escamilla, L Castro Castro, G Libreros Duque, D Diaz-Guio, F Benítez, A Guerra Urrego, R Buitrago, G Ortiz, M Villalba Gaviria, D Salas, J Ramirez-Arce, E Salgado, D Morocho, J Vergara, M Chung Sang, C Orellana-Jimenez, L Garrido, O Diaz, D Resiere, C Osorio, A De La Vega, R Carrillo, V Sanchez, A Villagomez, R Martinez Zubieta, M Sandia, M Zalatiel, M Poblano, D Rodriguez Gonzalez, F Arrazola, L Juan Francisco, S A Ñamendys-Silva, M Hernandez, D Rodriguez Cadena, I Lopez Islas, C Ballesteros Zarzavilla, A Matos, I Oyanguren, J Cerna, R Quispe Sierra, R Jimenez, L Castillo, R Ocal, A Sencan, S Mareque Gianoni, A Deicas, J Hurtado, G Burghi, A Martinelli, I Von Der Osten, C Du Maine, M Bhattacharyya, S Bandyopadhyay, S Yanamala, P Gopal, S Sahu, M Ibrahim, D Rathod, N Mukundan, A Dewan, P Amin, S Samavedam, B Shah, D Gurupal, B Lahkar, A Mandal, M Sircar, S Ghosh, V Balasubramani, F Kapadia, S Vadi, K Nair, S Tripathy, S Nandakumar, J Sharma, A Kar, S Jha, K Zirpe-Gurav, M Patel, A Bhavsar, D Samaddar, A Kulkarni, M Hashmi, W Ali, S Nadeem, K Indraratna, A Margarit, P Urbanek, J Schlieber, J Reisinger, J Auer, A Hartjes, A Lerche, T Janous, E Kink, W Krahulec, K Smolle, M Van Der Schueren, P Thibo, M Vanhoof, I Ahmet, G Philippe, P Dufaye, O Jacobs, V Fraipont, P Biston, A Dive, Y Bouckaert, E Gilbert, B Gressens, E Pinck, V Collin, J L Vincent, J De Waele, R Rimachi, D Gusu, K De Decker, K Mandianga, L Heytens, X Wittebole, S Herbert, V Olivier, W Vandenheede, P Rogiers, P Kolodzeike, M Kruse, T Andersen, V Harjola, K Saarinen, M Leone, A Durocher, S Moulront, A Lepape, M Losser, P Cabaret, E Kalaitzis, E Zogheib, P Charve, B Francois, J Y Lefrant, B Beilouny, X Forceville, B Misset, F Jacobs, F Bernard, D Payen, A Wynckel, V Castelain, A Faure, P Lavagne, L Thierry, M Moussa, A Vieillard-Baron, M Durand, M Gainnier, C Ichai, S Arens, C Hoffmann, M Kaffarnik, C Scharnofske, I Voigt, C Peckelsen, M Weber, J Gille, A Lange, G Schoser, A Sablotzki, U Jaschinski, A Bluethgen, F Vogel, A Tscheu, T Fuchs, M Wattenberg, T Helmes, S Scieszka, M Heintz, S Sakka, J Kohler, F Fiedler, M Danz, Y Sakr, R Riessen, T Kerz, A Kersten, F Tacke, G Marx, T Volkert, A Schmutz, A Nierhaus, S Kluge, P Abel, R Janosi, S Utzolino, H Bracht, S Toussaint, M Giannakou Peftoulidou, P Myrianthefs, A Armaganidis, C Routsi, A Xini, E Mouloudi, I Kokoris, G Kyriazopoulos, S Vlachos, A Lavrentieva, P Partala, G Nakos, A Moller, S Stefansson, J Barry, R O'Leary, C Motherway, M Faheem, E Dunne, M Donnelly, T Konrad, E Bonora, C Achilli, S Rossi, G Castiglione, A Peris, D Albanese, N Stocchetti, G Citerio, L Mozzoni, E Sisillo, P De Negri, M Savioli, P Vecchiarelli, F Puflea, V Stankovic, G Minoja, S Montibeller, P Calligaro, R Sorrentino, M Feri, M Zambon, E Colombaroli, A Giarratano, T Pellis, C Capra, M Antonelli, A Gullo, C Chelazzi, A De Capraris, N Patroniti, M Girardis, F Franchi, G Berlot, M Buttigieg, H Ponssen, J Ten Cate, L Bormans, S Husada, M Buise, B Van Der Hoven, A Reidinga, M Kuiper, P Pickkers, G Kluge, S Den Boer, J Kesecioglu, H Van Leeuwen, H Flaatten, S Mo, V Branco, F Rua, E Lafuente, M Sousa, N Catorze, M Barros, L Pereira, A Vintém De Oliveira, J Gomes, I Gaspar, M Pereira, M Cymbron, A Dias, E Almeida, S Beirao, I Serra, R Ribeiro, P Povoa, F Faria, Z Costa-E-Silva, J Nóbrega, F Fernandes, J Gabriel, G Voga, E Rupnik, L Kosec, M Kerin Povšic, I Osojnik, V Tomic, A Sinkovic, J González, E Zavala, J Pérez Valenzuela, L Marina, P Vidal-Cortés, P Posada, A Ignacio Martin-Loeches, N Muñoz Guillén, M Palomar, J Sole-Violan, A Torres, M Gonzalez Gallego, G Aguilar, R Montoiro Alluév, M Argüeso, M Parejo, M Palomo Navarro, A Jose, N Nin, F Alvarez Lerma, O Martinez, E Tenza Lozano, S Arenal López, M Perez Granda, S Moreno, C Llubia, C De La Fuente Martos, P Gonzalez-Arenas, N Llamas Fernández, B Gil Rueda, I Estruch Pons, N Cruza, F Maroto, A Estella, A Ferrer, L Iglesias Fraile, B Quindos, A Quintano, M Tebar, P Cardinal, A Reyes, A Rodríguez, A Abella, S García Del Valle, S Yus, E Maseda, J Berezo, A Tejero Pedregosa, C Laplaza, R Ferrer, J Rico-Feijoo, M Rodríguez, P Monedero, K Eriksson, D Lind, D Chabanel, H Zender, K Heer, B Frankenberger, S Jakob, A Haller, S Mathew, R Downes, C Barrera Groba, A Johnston, R Meacher, R Keays, P Haji-Michael, C Tyler, A Ferguson, S Jones, D Tyl, A Ball, J Vogel, M Booth, P Downie, M Watters, S Brett, M Garfield, L Everett, S Heenen, S Dhir, Z Beardow, M Mostert, S Brosnan, N Pinto, S Harris, A Summors, N Andrew, A Rose, R Appelboam, O Davies, E Vickers, B Agarwal, T Szakmany, S Wimbush, I Welters, R Pearse, R Hollands, J Kirk-Bayley, N Fletcher, B Bray, D Brealey
Rok vydání: 2017
Předmět:
Internationality
Time Factors
Databases
Factual
medicine.medical_treatment
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Settore MED/41 - Anestesiologia
Critical Care and Intensive Care Medicine
law.invention
0302 clinical medicine
law
Risk Factors
80 and over
030212 general & internal medicine
Hospital Mortality
610 Medicine & health
Aged
80 and over
Medical Audit
fluid output
Middle Aged
Water-Electrolyte Balance
fluid administration
Intensive care unit
outcome
septic shock
Adult
Aged
Humans
Intensive Care Units
Sepsis
Fluid Therapy
Cohort
Human
Cohort study
medicine.medical_specialty
Time Factor
Sepsi
Intensive Care Unit
Observational Study
03 medical and health sciences
Databases
Hemofiltration
medicine
Journal Article
Risk factor
Intensive care medicine
Factual
Hetastarch
business.industry
Septic shock
Risk Factor
030208 emergency & critical care medicine
fluid administration
fluid output
outcome
septic shock
medicine.disease
business
Zdroj: CRITICAL CARE MEDICINE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Critical Care Medicine, 45, 3, pp. 386-394
Critical Care Medicine, 45(3), 386. Lippincott Williams and Wilkins
Critical Care Medicine, 45, 386-394
ISSN: 0090-3493
Popis: Contains fulltext : 177598.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance. For this analysis, we included only the 1,808 patients with an admission diagnosis of sepsis. Patients were stratified according to quartiles of cumulative fluid balance 24 hours and 3 days after ICU admission. MEASUREMENTS AND MAIN RESULTS: ICU and hospital mortality rates were 27.6% and 37.3%, respectively. The cumulative fluid balance increased from 1,217 mL (-90 to 2,783 mL) in the first 24 hours after ICU admission to 1,794 mL (-951 to 5,108 mL) on day 3 and decreased thereafter. The cumulative fluid intake was similar in survivors and nonsurvivors, but fluid balance was less positive in survivors because of higher fluid output in these patients. Fluid balances became negative after the third ICU day in survivors but remained positive in nonsurvivors. After adjustment for possible confounders in multivariable analysis, the 24-hour cumulative fluid balance was not associated with an increased hazard of 28-day in-hospital death. However, there was a stepwise increase in the hazard of death with higher quartiles of 3-day cumulative fluid balance in the whole population and after stratification according to the presence of septic shock. CONCLUSIONS: In this large cohort of patients with sepsis, higher cumulative fluid balance at day 3 but not in the first 24 hours after ICU admission was independently associated with an increase in the hazard of death.
Databáze: OpenAIRE
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