Flocculation of Unsensitized Bentonite Particles by Cancer Serum
| Autor: | Marta Cancio, Amina Rivera de Sala, José Oliver-Gonzalez |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Flocculation
General Biochemistry Genetics and Molecular Biology Ancylostomiasis Serology Arthritis Rheumatoid Hookworm Infections Antigen In vivo Leprosy Neoplasms Alpha-Globulins medicine Humans Lupus Erythematosus Systemic Schistosomiasis Tuberculosis Syphilis Trichuriasis Alpha globulin Ascariasis biology Chemistry Arthritis Research Cancer Glomerulonephritis Complement System Proteins medicine.disease Immunology Bentonite biology.protein Aluminum Silicates Antibody |
| Zdroj: | Experimental Biology and Medicine. 116:409-411 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-116-29262 |
| Popis: | Discussion and summaryThe high degree of flocculation of unsensitized particles of bentonite by cancer sera and not by normal or by sera from other disease conditions, may be of help in developing a test for cancer diagnosis. Heating of the sera at 50°C for 30 minutes is required to establish the difference in reactivity between cancer and other sera. The factors affected by such heat treatment are not yet clear.Although the flocculation reaction occurs in cancer sera in a gradient and at high titers, no other indication could be found to show that this may be an antigen-antibody reaction, as could have been expected if the bentonite particles became coated with either excess antigen or antibody present in the sera. Also, addition of guinea pig complement did not restore the reaction in sera heated to 56OC for 30 minutes. Since in vivo antigen-antibody interaction has been considered to take place in some acute or chronic diseases such as systemic lupus erythematosus and glomerulonephritis, this theory sh... |
| Databáze: | OpenAIRE |
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