Milk polar lipids favorably alter circulating and intestinal ceramide and sphingomyelin species in postmenopausal women

Autor: Chloé Robert, Marie-Caroline Michalski, Nadine Leconte, Manon Lecomte, Laurie Joumard-Cubizolles, David Cheillan, Karène Bertrand, Anne-Esther Breyton, Emmanuel Combe, Annie Durand, Mélanie Le Barz, Florent Joffre, Martine Laville, Corinne Malpuech-Brugère, Cécile Vors, Michèle Trauchessec, Lemlih Ouchchane, Charlotte Cuerq, Sandra Pesenti, Patrice Gaborit, Hubert Vidal, Eddy Cotte, Jocelyne Drai, Stéphanie Lambert-Porcheron, Emmanuelle Meugnier, Emmanuelle Loizon, Annick Bernalier-Donadille
Přispěvatelé: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Corps Gras, (ITERG), Hospices Civils de Lyon, Unité Maladies Héréditaires du Métabolisme, Service de Biochimie et Biologie, Centre, Hospices Civils de Lyon, Unité de Nutrition Endocrinologie Métabolisme, Service de Biochimie, ACTALIA, Dairy Products and Technologies, Science et Technologie du Lait et de l'Oeuf (STLO), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Microbiologie Environnement Digestif Santé (MEDIS), Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite, Service de Chirurgie Digestive, Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Grenoble Alpes (UGA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, FUNDINGS. Agence Nationale de la Recherche, ANR-11-ALID-007-01, Regional Hospital Clinical Research Program (PHRCI-2014: VALOBAB, n°14-007), French Dairy Interbranch Organization (CNIEL), Groupe Lipides et Nutrition (GLN 2018-11-07), Hospices Civils de Lyon as sponsor., Giboulot, Anne, Actalia - division produits laitiers, Actalia [Saint-Lô], Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
chemistry.chemical_compound
Feces
0302 clinical medicine
Cheese
maladie cardiovasculaire
Gastrointestinal tract
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
food and beverages
General Medicine
Cardiovascular disease
3. Good health
Sphingomyelins
Postmenopause
Postprandial
Cholesterol
Milk
030220 oncology & carcinogenesis
lipide polaire
Female
lipids (amino acids
peptides
and proteins)
Sphingomyelin
medicine.medical_specialty
Ceramide
sphingomyéline
Ceramides
03 medical and health sciences
intestin
Internal medicine
medicine
Animals
Humans
Clinical Trials
Lipid rafts
Glycoproteins
business.industry
lipide du lait
ménopause
Metabolism
Lipid Droplets
Overweight
Lipid Metabolism
Diet
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
030104 developmental biology
Endocrinology
chemistry
Clinical Medicine
Glycolipids
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Chylomicron
Zdroj: JCI Insight
JCI Insight, American Society for Clinical Investigation, 2021, ⟨10.1172/jci.insight.146161⟩
JCI Insight, 2021, ⟨10.1172/jci.insight.146161⟩
ISSN: 2379-3708
Popis: International audience; BACKGROUND. High circulating levels of ceramides (Cer) and sphingomyelins (SM) have been associated with cardiometabolic diseases. The consumption of whole-fat dairy products, which naturally contain such polar lipids (PL), is associated with health benefits, but the impact on sphingolipidome remains unknown. We investigated how milk PL supplementation impacts circulating and intestinal SM and Cer composition in association with improvement of cardiovascular markers.METHODS. In a 4 week-randomized double-blind controlled study, 58 postmenopausal women consumed daily a cream cheese containing 0, 3 or 5 g of milk PL. Postprandial metabolic explorations were performed before and after the supplementation. SM and Cer species were analyzed in serum, intestine-derived chylomicrons and feces. The ileal content of 4 ileostomy patients was also explored after milk PL intake in a crossover double-blind study.RESULTS. Milk PL consumption decreased serum atherogenic C24:1 Cer (Pgroup = 0.033), C16:1 (Pgroup = 0.007) and C18:1 (Pgroup = 0.003) SM species. Changes in serum C16+18 SM species were positively correlated with the reduction of total cholesterol (r = 0.706, P < 0.001), LDL-C (r = 0.666, P < 0.001) and ApoB (r = 0.705, P < 0.001). Milk PL decreased the concentration in chylomicrons of total SM (Pgroup < 0.0001) and of C24:1 Cer (Pgroup = 0.001). Saturated SM and Cer species, which are also the major species found in milk PL-enriched cheeses, increased in ileal efflux and feces. There was a marked increase in total fecal Cer after milk PL supplementation (Pgroup = 0.0002). Milk PL also modulated the abundance of some specific SM and Cer species in ileal efflux and feces, suggesting differential absorption and metabolization processes in the gut.CONCLUSION. These data demonstrate that milk PL supplementation decreases atherogenic SM and Cer species associated with an improvement of cardiovascular risk markers. Our findings bring new insights on sphingolipid metabolism in the gastrointestinal tract, especially Cer as such signaling molecules potentially participating in the beneficial effect of milk PL. ClinicalTrials.gov, NCT02099032, NCT02146339.
Databáze: OpenAIRE
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