Activation of blood coagulation in cancer: implications for tumour progression

Autor: Luize G. Lima, Robson Q. Monteiro
Jazyk: angličtina
Rok vydání: 2013
Předmět:
MV
microvesicle
Cell
lcsh:Life
lcsh:QR1-502
Review Article
Biochemistry
Trousseau’s syndrome
lcsh:Microbiology
Metastasis
NET
neutrophil extracellular trap
Neoplasms
Neoplasm Metastasis
Receptor
FIX
factor IX
PS
phosphatidylserine
Thrombosis
VEGF
vascular endothelial growth factor
Blood Coagulation Factors
medicine.anatomical_structure
Coagulation
FVIIa
factor VIIa
Disease Progression
MMP
matrix metalloprotease
FX
factor X
NK
natural killer
protease-activated receptor
S1
Biophysics
Antineoplastic Agents
Biology
blood coagulation
Tissue factor
medicine
Animals
Humans
metastasis
Molecular Biology
tumour growth
Cancer
Anticoagulants
Cell Biology
FVIII
factor VIII
medicine.disease
tissue factor
Microvesicles
lcsh:QH501-531
Immunology
TF
tissue factor
Cancer research
PAR
protease-activated receptor
Zdroj: Bioscience Reports, Vol 33, Iss 5, p e00064 (2013)
Bioscience Reports
ISSN: 1573-4935
0144-8463
Popis: Several studies have suggested a role for blood coagulation proteins in tumour progression. Herein, we discuss (1) the activation of the blood clotting cascade in the tumour microenvironment and its impact on primary tumour growth; (2) the intravascular activation of blood coagulation and its impact on tumour metastasis and cancer-associated thrombosis; and (3) antitumour therapies that target blood-coagulation-associated proteins. Expression levels of the clotting initiator protein TF (tissue factor) have been correlated with tumour cell aggressiveness. Simultaneous TF expression and PS (phosphatidylserine) exposure by tumour cells promote the extravascular activation of blood coagulation. The generation of blood coagulation enzymes in the tumour microenvironment may trigger the activation of PARs (protease-activated receptors). In particular, PAR1 and PAR2 have been associated with many aspects of tumour biology. The procoagulant activity of circulating tumour cells favours metastasis, whereas the release of TF-bearing MVs (microvesicles) into the circulation has been correlated with cancer-associated thrombosis. Given the role of coagulation proteins in tumour progression, it has been proposed that they could be targets for the development of new antitumour therapies.
Databáze: OpenAIRE
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