Neurobeachin regulates neurotransmitter receptor trafficking to synapses
| Autor: | Nancy E. Cooke, SangYong Jung, Manfred W. Kilimann, Ramya Nair, Juliane Lauks, Nils Brose, Heidi de Wit, Jeong-Seop Rhee, Matthijs Verhage |
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| Přispěvatelé: | Human genetics, NCA - Brain mechanisms in health and disease, Functional Genomics, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Physiology
Kainate receptor Nerve Tissue Proteins Neurotransmission Biology Receptors N-Methyl-D-Aspartate Synaptic Transmission Article 03 medical and health sciences Mice 0302 clinical medicine Receptors Kainic Acid Neurotransmitter receptor hemic and lymphatic diseases Animals SDG 14 - Life Below Water Long-term depression Research Articles 030304 developmental biology Mice Knockout 0303 health sciences Membrane Proteins Cell Biology Receptors GABA-A Cell biology Protein Transport Silent synapse Synaptic plasticity Synapses Carrier Proteins Postsynaptic density Ion channel linked receptors 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology Journal of Cell Biology, 200(1), 61-80. Rockefeller University Press The Journal of Cell Biology; Vol 200 Nair, R, Lauks, J, Jung, S, Cooke, N E, de Wit, H, Brose, N, Kilimann, M W, Verhage, M & Rhee, J 2013, ' Neurobeachin regulates neurotransmitter receptor trafficking to synapses ', Journal of Cell Biology, vol. 200, no. 1, pp. 61-80 . https://doi.org/10.1083/jcb.201207113 |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.201207113 |
| Popis: | Neurobeachin regulates synaptic transmission by targeting neurotransmitter receptors to synapses under basal conditions. The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had strongly reduced synaptic responses caused by a reduction in surface levels of glutamate and GABAA receptors. In the absence of Nbea, immature AMPA receptors accumulated early in the biosynthetic pathway, and mature N-methyl-d-aspartate, kainate, and GABAA receptors did not reach the synapse, whereas maturation and surface expression of other membrane proteins, synapse formation, and presynaptic function were unaffected. These data show that Nbea regulates synaptic transmission under basal conditions by targeting neurotransmitter receptors to synapses. |
| Databáze: | OpenAIRE |
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