Growth and developmental outcomes of three high-risk infant rhesus macaques (Macaca mulatta)
| Autor: | Lisa A. Houser, Amanda M. Dettmer, Gerald C. Ruppenthal, Saverio Capuano, Laura Hewitson |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Birth weight Intrauterine growth restriction Cognition Pregnancy Risk Factors biology.animal Cognitive development Animals Medicine Primate Ecology Evolution Behavior and Systematics Motor skill Behavior Animal biology business.industry Socialization Gestational age medicine.disease Macaca mulatta Animals Newborn Motor Skills Immunology Gestation Female Animal Science and Zoology business |
| Zdroj: | American Journal of Primatology. 69:503-518 |
| ISSN: | 1098-2345 0275-2565 |
| DOI: | 10.1002/ajp.20349 |
| Popis: | Infants classified as “high risk” are born with a greater chance of developing medical complications at birth, and may have cognitive and other developmental complications later in life. Very few reports exist regarding the survival and outcome of such infants in primate colonies. Here we present early growth and developmental data on three high-risk infant rhesus macaques (one female and two males) that were born either with intrauterine growth restriction (IUGR; born below the 1st birth weight percentile for gestational age) or extremely prematurely (at gestational days 128 and 140; mean full-term gestation=164 days). We compared the outcome of these infants with that of healthy controls born at term and found no gross developmental delays in these infants with respect to growth, neonatal reflex and motor skill development, early cognitive development, or social behavior. Neurological and cognitive assessments were compared in terms of both postnatal and gestational age. The survival of these infants was dependent on a 24-hr staffed nursery and a fluid protocol that catered to each high-risk infant's individual needs. When such measures are implemented, infants such as these have a good chance of survival and can serve as excellent models for high-risk human babies and their subsequent development. Am. J. Primatol. 69:503–518, 2007. © 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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