Gut microbiome diversity in acute infective and chronic inflammatory gastrointestinal diseases in North India
| Autor: | Jaishree Paul, Saurabh Kedia, Vineet Ahuja, Ritika Rampal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Population India Inflammatory bowel disease Microbiology 03 medical and health sciences Feces fluids and secretions 0302 clinical medicine Crohn Disease Medicine Humans Microbiome Intestinal Mucosa education education.field_of_study Crohn's disease biology business.industry Gastrointestinal Microbiome Gastroenterology biology.organism_classification medicine.disease Ulcerative colitis Peptostreptococcus 030104 developmental biology Immunology Dysentery Amebic 030211 gastroenterology & hepatology Colitis Ulcerative Bacteroides business |
| Zdroj: | Journal of gastroenterology. 51(7) |
| ISSN: | 1435-5922 |
| Popis: | The disease profile in the Indian population provides a unique opportunity for studying the host microbiome interaction in both infectious (amebiasis) and autoimmune diseases like inflammatory bowel disease (IBD) from a similar environment and genetic background. Analysis of fecal samples from untreated amebic liver abscess (ALA) patients, Entamoeba histolytica (Eh)-negative and -positive asymptomatic individuals, and pus samples from naive ALA patients revealed a significant reduction in Lactobacillus in asymptomatic individuals (Eh +ve) and ALA patients. Two anaerobic genera, namely Bacteroides and Peptostreptococcus, were detected in naive ALA pus samples. Analysis of fecal samples from amoebic colitis patients showed a significant decline in population of Bacteroides, Clostridium coccoides and leptum subgroup, Lactobacillus, Campylobacter, and Eubacterium, whereas a significant increase in Bifidobacterium was observed. Mucosa-associated bacterial flora analysis from IBD patients and healthy controls revealed a significant difference in concentration of bacteria among predominating and subdominating genera between ulcerative colitis (UC), Crohn's disease (CD) patients, and controls. In contrast to the mucosal studies, we found a significant increase in lactobacilli population in fecal samples of active UC patients. Another study revealed a significant decrease of Clostridium coccoides and leptum clusters in fecal samples of active UC patients along with decreased concentrations of fecal SCFAs, especially of n-butyrate, iso-butyrate, and acetate. We therefore found similar perturbations in gut microbiome in both infectious and autoimmune diseases, indicating inflammation to be the major driver for changes in gut microbiome. |
| Databáze: | OpenAIRE |
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