Capecitabine-mediated heart failure in colorectal cancer: a case series
| Autor: | Benjamin A Goldenberg, Davinder S Jassal, Erin N. McAndrew, Christina Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Myocarditis Heart failure 030204 cardiovascular system & hematology Sudden cardiac death Capecitabine 03 medical and health sciences 0302 clinical medicine Cardiac magnetic resonance imaging Internal medicine Case report Medicine Case Series AcademicSubjects/MED00200 Cardiogenic shock Cardiotoxicity medicine.diagnostic_test business.industry medicine.disease Cardio-oncology 030220 oncology & carcinogenesis Cardiology cardiovascular system Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | European Heart Journal: Case Reports |
| ISSN: | 2514-2119 |
| Popis: | Background Capecitabine is a pyrimidine antimetabolite that inhibits thymidylate synthase and is commonly used in the treatment of colorectal cancer. Adverse cardiac side effects are reported in 1–18% of patients receiving Capecitabine. The most commonly proposed mechanism of cardiotoxicity in the setting of Capecitabine use is vasospasm of the coronary arteries. However, cardiotoxicity can also present as an acute coronary syndrome, arrhythmia, hypertension, and/or sudden cardiac death. Profound non-vasospastic cardiotoxicity is rare. Case summary We describe two cases of acute heart failure leading to cardiogenic shock in patients shortly after exposure to Capecitabine. Both patients did not demonstrate the characteristic transient ST elevation seen in patients with coronary artery vasospasms secondary to Capecitabine. Both patients required admission to the Acute Cardiac Care Unit requiring vasopressor and inotropic support. Thorough diagnostic investigations including echocardiography, cardiac magnetic resonance imaging, and cardiac computed tomography did not identify infarction, myocarditis, or any infiltrative process to explain their symptoms. Both patients had complete resolution of cardiac function, with no long-term sequalae. Discussion In patients receiving Capecitabine, reversible heart failure leading to cardiogenic shock should be considered as a potential cardiotoxic side effect. |
| Databáze: | OpenAIRE |
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