Vinorelbine, epirubicin, and methotrexate (VEM) as primary treatment in locally advanced breast cancer
| Autor: | J. Abrahamova, M. Wagnerova, V. Malec, I. Sirakova, D. Kroslakova, I. Van Praagh, J. Prausova, P. Tuma, E. Simova, I. Pavlikova, E. Pavlikova, E. Kubala, D. Machova, I. Kocak |
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| Rok vydání: | 2001 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Neutropenia Adolescent Locally advanced Breast Neoplasms Vinorelbine Vinblastine Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Mastectomy Aged Epirubicin Neoplasm Staging business.industry Middle Aged medicine.disease Survival Rate Regimen Methotrexate Treatment Outcome Primary treatment Female Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | The oncologist. 6(4) |
| ISSN: | 1083-7159 |
| Popis: | Purpose. This phase II trial of VEM (vinorelbine + epirubicine + methotrexate) in the treatment of locally advanced breast cancer was conducted to obtain downstaging to allow surgery and breast conservation. Patients and Methods. This multicenter study recruited 58 patients with locally advanced breast cancer (two patients ineligible); 56 were evaluable for response and tolerance. Results. Downstaging was obtained in 77% of the patients with a pathological complete response (pCR) rate of 9%. At 33 months of follow-up, median survival has not been reached. Neutropenia grade 3-4 was reported in 31% of cycles with 3% of cycles with infection grade 3. Alopecia grade 3 was noticed for 71% of patients. Conclusion. VEM represents an effective regimen for patients with locally advanced breast cancer, allowing an important pCR. Moreover, this regimen appears to be particularly well tolerated. |
| Databáze: | OpenAIRE |
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