Biliary elimination of apalcillin in cholecystectomized patients
| Autor: | C. M. Harnoss, Klaus Borner, B.M. Harnoss, Peter Koeppe, Hartmut Lode |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Metabolic Clearance Rate medicine.medical_treatment Antibiotics Biliary Elimination Gastroenterology Excretion Pharmacokinetics Internal medicine Drug Discovery Healthy volunteers medicine Bile Humans Pharmacology (medical) Cholecystectomy Infusions Parenteral Naphthyridines Apalcillin Aged Pharmacology business.industry General Medicine Middle Aged Major duodenal papilla Infectious Diseases Oncology Ampicillin Female business |
| Zdroj: | Chemotherapy. 31(4) |
| ISSN: | 0009-3157 |
| Popis: | Pharmacokinetic examinations were performed in 5 patients with bile-duct drainage following cholecystectomy and choledochus revision with 2 g of apalcillin over 20 min intravenously. In comparison to healthy volunteers they had significantly longer half-life values and long persisting serum concentrations over a period of 24 h. The biliary elimination rate of apalcillin correlated with the hepatic function of the patients and was with 4.3% on the average distinctly lower than that of healthy volunteers, whereby the bile, however, could probably not be collected quantitatively in cases of open papilla. Compensatory excretion of apalcillin took place via the kidneys and, considering the metabolites A1 and A2, it amounted to a total of 73%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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