GALAD Score for Hepatocellular Carcinoma Detection in Comparison with Liver Ultrasound and Proposal of GALADUS Score
| Autor: | Mindie H. Nguyen, Kristin C. Mara, Jianliang Dai, Benyam D. Addissie, Sravanthi Lavu, J. Paul Theobald, Nasra H. Giama, Gregory J. Gores, Jo Ann Rinaudo, Ju Dong Yang, William S. Harmsen, Hamdi A. Ali, Jorge A. Marrero, Catherine D. Moser, Fatima Hassan, K. Rajender Reddy, Loretta K. Allotey, Ziding Feng, Melissa Ward, Alex S. Befeler, Jessica L. Cvinar, Alicia Algeciras-Schimnich, Lewis R. Roberts, Nicha Wongjarupong, Denise M. Harnois, Myron Schwartz, Hawa M. Ali, Hiroyuki Yamada, Katsuyuki Miyabe, Sudhir Srivastava, Ning Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Epidemiology Single Center Chronic liver disease Gastroenterology Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Stage (cooking) Early Detection of Cancer Ultrasonography business.industry Liver Neoplasms Middle Aged Prognosis medicine.disease digestive system diseases Confidence interval 030104 developmental biology ROC Curve Oncology Case-Control Studies 030220 oncology & carcinogenesis Hepatocellular carcinoma Cohort Female business Cohort study |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 28:531-538 |
| ISSN: | 1538-7755 1055-9965 |
| Popis: | Background: The GALAD score is a serum biomarker–based model that predicts the probability of having hepatocellular carcinoma (HCC) in patients with chronic liver disease. We aimed to assess the performance of the GALAD score in comparison with liver ultrasound for detection of HCC. Methods: A single-center cohort of 111 HCC patients and 180 controls with cirrhosis or chronic hepatitis B and a multicenter cohort of 233 early HCC and 412 cirrhosis patients from the Early Detection Research Network (EDRN) phase II HCC Study were analyzed. Results: The area under the ROC curve (AUC) of the GALAD score for HCC detection was 0.95 [95% confidence interval (CI), 0.93–97], which was higher than the AUC of ultrasound (0.82, P Conclusions: The performance of the GALAD score was superior to ultrasound for HCC detection. The GALADUS score further enhanced the performance of the GALAD score. Impact: The GALAD score was validated in the United States. |
| Databáze: | OpenAIRE |
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