Association between HLA-A/-B antigens and -DRB1 alleles and nasopharyngeal carcinoma in Tunisia
| Autor: | Farhat Ben Ayed, Abderrahmen Ladgham, Nehla Mokni-Baizig, Faiçal Sassi, Omrane Bel Hadj, Ahmed El May, S. Ayed, Khaled Ayed |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Cancer Research Tunisia Adolescent Genotype Human leukocyte antigen Biology Antigen otorhinolaryngologic diseases Carcinoma medicine Humans Child HLA-DRB1 Alleles Aged HLA-A Antigens Incidence HLA-DR1 Antigen Nasopharyngeal Neoplasms General Medicine Middle Aged medicine.disease HLA-B HLA-A stomatognathic diseases Phenotype Oncology Nasopharyngeal carcinoma HLA-B Antigens Case-Control Studies Immunology Carcinoma Squamous Cell Female |
| Zdroj: | Oncology. 61(1) |
| ISSN: | 0030-2414 |
| Popis: | Using serologic and molecular methods, 45 nasopharyngeal carcinoma (NPC) patients were typed for HLA class I and class II and were compared to 100 unrelated normal Tunisians. Our results showed that the antigen frequency of HLA-B13 and allelic frequencies of DRB1*03, DRB1*15 were significantly higher in the NPC patients than in the control group (15.5 vs. 4; 26.4 vs. 11.5, and 14.4 vs. 6.5%, respectively) probably indicating a positive association with NPC. Moreover, we observed that HLA-A23 was absent in our NPC sample and was present in 18% of normal controls, and HLA-DRB1*11 was less frequent among the patients compared to the controls (5.5 vs. 14%) suggesting a protective effect of this association with NPC. |
| Databáze: | OpenAIRE |
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