Biocompatibility of silver nitrate and ofloxacine coated bioabsorbable SR-PLLA rods
| Autor: | Markku Multanen, Tero Välimaa, Pertti Törmälä, Teuvo L.J. Tammela, Jukka Seppälä, Kari Järvi, Martti Talja |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Dorsum Ofloxacin medicine.medical_specialty Biocompatibility Polymers Urology Anti-Infective Agents Urinary Positive control engineering.material Rod chemistry.chemical_compound Coated Materials Biocompatible Coating Absorbable Implants medicine Animals Lactic Acid Adhesion Biocompatible material Surgery Silver nitrate chemistry engineering Silver Nitrate Stents Rabbits Nuclear chemistry |
| Zdroj: | Urological Research. 29:113-117 |
| ISSN: | 1434-0879 0300-5623 |
| Popis: | The purpose of this study was to evaluate the biocompatibility of silver nitrate and ofloxacine coatings of bioresorbable self-reinforced poly-L-lactic acid (SR-PLLA) rods. SR-PLLA rods coated with pure poly(caprolactone-co-L-lactide) or blended with silver nitrate (10, 5 or 2 weight-%) or ofloxacine (5 or 2 weight-%) were implanted in the dorsal muscles of 25 male rabbits. Tissue reactions caused by implantation trauma were seen 1 week after implantation. The positive control and 10 w-% silver nitrate coating showed the most marked reactions 1 month after implantation. Only sparse reactions were seen 6 months after implantation. Tissue reactions were scored semi-quantitatively. As a result of this study, we concluded that silver nitrate or ofloxacine coatings up to five w-% did not alter the good biocompatibility of SR-PLLA essentially. The method may lead to the possibility of preventing bacterial adhesion to urological stents during insertion. |
| Databáze: | OpenAIRE |
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