Rapid Access to 3-Substituted Pyridines and Carbolines via a Domino, Copper-free, Palladium-Catalyzed Sonogashira Cross-Coupling/6π-Aza Cyclization Sequence

Autor:	Dilipkumar Uredi, Amarender Goud Burra, E. Blake Watkins
Rok vydání:	2021
Předmět:	Annulation Pyridines Aryl Organic Chemistry Sonogashira coupling chemistry.chemical_element Combinatorial chemistry Copper Domino Catalysis chemistry.chemical_compound chemistry Cyclization Selectivity Palladium Carbolines
Zdroj:	The Journal of organic chemistry. 86(24)
ISSN:	1520-6904
Popis:	Herein, we report a one-pot, three-component method for the preparation of 3-substituted pyridines and carbolines via copper-free, palladium-catalyzed Sonogashira cross-coupling with aryl iodides, followed by 6π-aza cyclization. This arylation cross-coupling/annulation cascade provides easy access to substituted, fused pyridines from readily available substrates in good yields (67-92%) with complete selectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fe14fbde5502c87a29e087a52f10a2 https://pubmed.ncbi.nlm.nih.gov/34846892 Zobrazit plný text záznamu