Estimating the Sensory Irritating Potency of Airborne Nonreactive Volatile Organic Chemicals and Their Mixtures
| Autor: | Michelle Schaper, Gunnar Damgård Nielsen, Michael H. Abraham, Yves Alarie |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Indoor air
Skin Absorption Bioengineering Sensory system medicine.disease_cause Lethal Dose 50 Mice Structure-Activity Relationship Drug Discovery medicine Low exposure Animals Humans Potency Organic chemicals Chemistry Hydrogen Bonding Environmental Exposure General Medicine Hydrocarbons Air Pollution Indoor Environmental chemistry Irritants Regression Analysis Molecular Medicine Volatilization Irritation |
| Zdroj: | SAR and QSAR in Environmental Research. 5:151-165 |
| ISSN: | 1029-046X 1062-936X |
| Popis: | This article describes the possibility of estimating whether or not a mixture of nonreactive volatile organic chemicals (NRVOC) is likely to elicit complaints of sensory irritation in humans. For this estimation we rely on: a) the sensory irritating potency of individual NRVOC can be estimated from a variety of physicochemical properties of these chemicals, b) at low exposure concentrations, the additivity rule can be applied using the potency of each chemical in a mixture and c) a threshold concentration exists below which no sensory irritation will occur. We used this estimating approach and we compared the results obtained with those obtained experimentally in humans exposed to a well defined mixture. The approach presented can be used to arrive at a decision as to whether or not exposure to a mixture of NRVOC is likely to result in sensory irritation complaints by humans, either in the general indoor air situation or for industrial workers. |
| Databáze: | OpenAIRE |
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