Prognostic value of p21-activated kinase 4 in resected pancreatic cancer
Autor: | Haeryoung Kim, Jaihwan Kim, Yu Jung Kim, Yoo Seok Yoon, YoungRok Choi, Jin Won Kim, Keun Wook Lee, Jin-Hyeok Hwang, Ho-Seong Han, Ji Won Kim, Sehhoon Park, Jee Hyun Kim, Jai Young Cho |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Adenocarcinoma Gastroenterology Thymidylate synthase Pathology and Forensic Medicine Equilibrative Nucleoside Transporter 1 03 medical and health sciences 0302 clinical medicine Recurrence Pancreatic cancer Internal medicine Biomarkers Tumor medicine Humans Immunology and Allergy Lymph node Aged Retrospective Studies Aged 80 and over Microscopy Univariate analysis Tissue microarray biology business.industry Hazard ratio Thymidylate Synthase General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Pancreatic Neoplasms 030104 developmental biology medicine.anatomical_structure p21-Activated Kinases Tissue Array Analysis 030220 oncology & carcinogenesis Cancer research biology.protein Female CA19-9 business |
Zdroj: | APMIS. 125:699-707 |
ISSN: | 0903-4641 |
Popis: | Resectable pancreatic cancer has a high recurrence rate after curative surgery. Biomarkers are needed for distinguishing patients who may benefit from curative resection. In this study, we sought to analyze the prognostic value of p21-activated kinase 1 (PAK1), p21-activated kinase 4 (PAK4), human equilibrative nucleoside transporter 1 (hENT1), and thymidylate synthase (TS) in surgically resected pancreatic ductal adenocarcinomas. A total of 160 pancreatic cancer patients who underwent surgery with curative intent were retrospectively reviewed. Tissue microarrays were constructed and immunohistochemical stains were performed for PAK1, PAK4, hENT1, and TS. The absence of PAK4 expression in pancreatic adenocarcinomas was associated with poorer histologic differentiation (p < 0.001), shorter overall survival [hazard ratio (HR) = 2.86, 95% confidence interval (CI) 1.43-5.71; p = 0.003], and disease-free survival (HR = 2.29, 95% CI: 1.11-4.74; p = 0.025) on univariate analyses. In addition, more frequent venous invasion and lymph node metastases were seen in PAK4-negative tumors although not statistically significant. PAK1, hENT1, and TS expression status did not have significant influences on patient survival. In conclusion, PAK4 of the markers tested in this study may be a potential prognostic biomarker for pancreatic adenocarcinomas. |
Databáze: | OpenAIRE |
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