Prognostic value of p21-activated kinase 4 in resected pancreatic cancer

Autor: Haeryoung Kim, Jaihwan Kim, Yu Jung Kim, Yoo Seok Yoon, YoungRok Choi, Jin Won Kim, Keun Wook Lee, Jin-Hyeok Hwang, Ho-Seong Han, Ji Won Kim, Sehhoon Park, Jee Hyun Kim, Jai Young Cho
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Adenocarcinoma
Gastroenterology
Thymidylate synthase
Pathology and Forensic Medicine
Equilibrative Nucleoside Transporter 1
03 medical and health sciences
0302 clinical medicine
Recurrence
Pancreatic cancer
Internal medicine
Biomarkers
Tumor
medicine
Humans
Immunology and Allergy
Lymph node
Aged
Retrospective Studies
Aged
80 and over
Microscopy
Univariate analysis
Tissue microarray
biology
business.industry
Hazard ratio
Thymidylate Synthase
General Medicine
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Survival Analysis
Pancreatic Neoplasms
030104 developmental biology
medicine.anatomical_structure
p21-Activated Kinases
Tissue Array Analysis
030220 oncology & carcinogenesis
Cancer research
biology.protein
Female
CA19-9
business
Zdroj: APMIS. 125:699-707
ISSN: 0903-4641
Popis: Resectable pancreatic cancer has a high recurrence rate after curative surgery. Biomarkers are needed for distinguishing patients who may benefit from curative resection. In this study, we sought to analyze the prognostic value of p21-activated kinase 1 (PAK1), p21-activated kinase 4 (PAK4), human equilibrative nucleoside transporter 1 (hENT1), and thymidylate synthase (TS) in surgically resected pancreatic ductal adenocarcinomas. A total of 160 pancreatic cancer patients who underwent surgery with curative intent were retrospectively reviewed. Tissue microarrays were constructed and immunohistochemical stains were performed for PAK1, PAK4, hENT1, and TS. The absence of PAK4 expression in pancreatic adenocarcinomas was associated with poorer histologic differentiation (p < 0.001), shorter overall survival [hazard ratio (HR) = 2.86, 95% confidence interval (CI) 1.43-5.71; p = 0.003], and disease-free survival (HR = 2.29, 95% CI: 1.11-4.74; p = 0.025) on univariate analyses. In addition, more frequent venous invasion and lymph node metastases were seen in PAK4-negative tumors although not statistically significant. PAK1, hENT1, and TS expression status did not have significant influences on patient survival. In conclusion, PAK4 of the markers tested in this study may be a potential prognostic biomarker for pancreatic adenocarcinomas.
Databáze: OpenAIRE
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