Acute Intravenous Injection Toxicity Study of IBZM and BZM in Rats
| Autor: | Fu-Fa Hsu, Lie-Hang Shen, Mei-Hsiu Liao, Tung-Chuan Chiang, An-Shoei Yang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pyrrolidines Time Factors Health Toxicology and Mutagenesis Central nervous system Contrast Media Pharmacology Toxicology Dose level Rats Sprague-Dawley chemistry.chemical_compound Iodobenzamide Toxicity Tests Acute Animals Medicine Benzamide Chemical Health and Safety business.industry Body Weight Public Health Environmental and Occupational Health Total body General Medicine Acute toxicity Rats medicine.anatomical_structure chemistry Dopamine receptor Anesthesia Benzamides Injections Intravenous Toxicity Dopamine Antagonists Female business |
| Zdroj: | Drug and Chemical Toxicology. 31:529-533 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.1080/01480540802393332 |
| Popis: | S-3-iodo-N-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-6-methoxybenzamide (IBZM) is one of the several benzamide derivatives showing a high affinity for the central nervous system (CNS) D2 dopamine receptor. Carrier-free [123I]IBZM is potentially useful as a nuclear medicine imaging agent for investigating the CNS D2 dopamine receptor in humans. This study describes the acute toxicity of IBZM and S-N-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-6-methoxybenzamide (BZM) in the rats. Treated rats were administered with IBZM at dose levels of 1 and 5 microg/kg and BZM at dose levels of 250 and 1250 microg/kg with dose volumes of 1 and 5 mL/kg. The control rats were administered 5 mL/kg of vehicle control. The rats were observed for 14 days. Observations included general demeanor, clinical signs, mortality, body weights/total body weight gains, and gross necropsy findings. None of the animals died during the 14-day study period. In female rats, the body weight gained at the first week of BZM treatment at a dose level of 1250 microg/kg and the total body weight gains of both IBZM treated groups were significantly higher than the control group (p < 0.05). |
| Databáze: | OpenAIRE |
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