Detection and genetic characterization of community-based SARS-CoV-2 infections – New York City, March 2020

Autor: Priya Nori, Jacob H. Rand, Lars F. Westblade, Suxiang Tong, Anna Uehara, Harjot K. Singh, Don Weiss, Gayle E Langley, Ljiljana V. Vasovic, Clinton R. Paden, Ying Tao, Sharon K. Greene, Jennifer L. Rakeman, Dena Bushman, Phi A. Lai, Jessica Sell, Karen A Alroy, Jessica L. Jacobson, Vishnu Singh, Christy Harrison, Page Keating, Amanda Wahnich, Preeti Pathela, Dakai Liu, Wendy Szymczak, Janice Burns, Erika P. Orner, David P. Calfee, Krista Queen, Nishant Prasad
Rok vydání: 2020
Předmět:
Male
Health (social science)
Epidemiology
Health
Toxicology and Mutagenesis
030230 surgery
01 natural sciences
0302 clinical medicine
Health Information Management
Health care
Pandemic
Immunology and Allergy
Medicine
Pharmacology (medical)
030212 general & internal medicine
Full Report
Child
Community based
biology
Transmission (medicine)
General Medicine
Middle Aged
Community-Acquired Infections
Child
Preschool
Female
Coronavirus Infections
Emergency Service
Hospital
Travel-Related Illness
Sequence Analysis
Adult
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Adolescent
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
Betacoronavirus
Young Adult
03 medical and health sciences
Environmental health
Humans
0101 mathematics
Pandemics
Aged
Transplantation
SARS-CoV-2
business.industry
Public health
010102 general mathematics
COVID-19
Infant
Outbreak
biology.organism_classification
New York City
business
Sentinel Surveillance
Zdroj: Morbidity and Mortality Weekly Report
ISSN: 1600-6135
Popis: To limit introduction of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), the United States restricted travel from China on February 2, 2020, and from Europe on March 13. To determine whether local transmission of SARS-CoV-2 could be detected, the New York City (NYC) Department of Health and Mental Hygiene (DOHMH) conducted deidentified sentinel surveillance at six NYC hospital emergency departments (EDs) during March 1-20. On March 8, while testing availability for SARS-CoV-2 was still limited, DOHMH announced sustained community transmission of SARS-CoV-2 (1). At this time, twenty-six NYC residents had confirmed COVID-19, and ED visits for influenza-like illness* increased, despite decreased influenza virus circulation.† The following week, on March 15, when only seven of the 56 (13%) patients with known exposure histories had exposure outside of NYC, the level of community SARS-CoV-2 transmission status was elevated from sustained community transmission to widespread community transmission (2). Through sentinel surveillance during March 1-20, DOHMH collected 544 specimens from patients with influenza-like symptoms (ILS)§ who had negative test results for influenza and, in some instances, other respiratory pathogens.¶ All 544 specimens were tested for SARS-CoV-2 at CDC; 36 (6.6%) tested positive. Using genetic sequencing, CDC determined that the sequences of most SARS-CoV-2-positive specimens resembled those circulating in Europe, suggesting probable introductions of SARS-CoV-2 from Europe, from other U.S. locations, and local introductions from within New York. These findings demonstrate that partnering with health care facilities and developing the systems needed for rapid implementation of sentinel surveillance, coupled with capacity for genetic sequencing before an outbreak, can help inform timely containment and mitigation strategies.
Databáze: OpenAIRE
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