The slug mucosal irritation (SMI) assay: Development of a screening tool for the evaluation of ocular discomfort caused by shampoos
| Autor: | Els Adriaens, Philippe Kestelyn, Jean Paul Remon, Joke Lenoir, Andre Klomp, Ilse Claerhout |
|---|---|
| Přispěvatelé: | Specialities |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Surfactant-based personal care products medicine.medical_specialty Human eye irritation test medicine.medical_treatment Ocular discomfort Gastropoda Hair Preparations Eye Toxicology medicine.disease_cause Surface-Active Agents Young Adult Double-Blind Method Predictive Value of Tests Toxicity Tests Evaluation methods medicine Animals Humans Screening tool Cross-Over Studies business.industry fungi Reproducibility of Results General Medicine Middle Aged Crossover study Dermatology eye diseases Shampoo Surgery Mucus Artificial tears Predictive value of tests Slug mucosal irritation assay Irritants Female Irritation business |
| Zdroj: | Toxicology in Vitro. 25:1919-1925 |
| ISSN: | 0887-2333 |
| DOI: | 10.1016/j.tiv.2011.06.009 |
| Popis: | In this research, the slug mucosal irritation (SMI) assay was applied to predict ocular discomfort caused by shampoos to investigate the correlation between responses in slugs and humans. Several SMI experiments and a human eye irritation test (HEIT) were performed with 1 artificial tear solution (ArtTear) and 5 shampoos (A-E; 5%-dilution). In the HEIT, evaluation was performed by participants and an ophthalmologist at several time points. Analyses reveal that (1) a significant positive association existed between immediate stinging reaction reported by the participants and the mean total mucus produced by the slugs (MTMP) (Spearman's Rank correlation=0.986, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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