Low incidence of severe bacterial infections in hospitalised patients with COVID-19 : A population-based registry study
| Autor: | M. J. Ahava, E. Kortela, E. Forsblom, A. Pätäri-Sampo, N. Friberg, A. Meretoja, S.-M. Kivivuori, M. Lappalainen, S. Kurkela, A. Järvinen, H. Jarva |
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| Přispěvatelé: | HUSLAB, Helsinki University Hospital Area, University of Helsinki, HUS Diagnostic Center, HUS Inflammation Center, Infektiosairauksien yksikkö, Clinicum, HUS Children and Adolescents, Children's Hospital, Department of Virology, Medicum, Olli Pekka Vapalahti / Principal Investigator, Viral Zoonosis Research Unit, Department of Medicine, Research Programs Unit, Department of Bacteriology and Immunology, TRIMM - Translational Immunology Research Program |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Microbiology (medical)
respiratory infections Infectious Diseases General Immunology and Microbiology bloodstream infections COINFECTIONS SARS-CoV-2 severe bacterial infection 3121 General medicine internal medicine and other clinical medicine nosocomial infections INVASIVE PULMONARY ASPERGILLOSIS COVID-19 General Medicine |
| Popis: | Background Bacterial infections complicating COVID-19 are rare but present a challenging clinical entity. The aim of this study was to evaluate the incidence, aetiology and outcome of severe laboratory-verified bacterial infections in hospitalised patients with COVID-19. Methods All laboratory-confirmed patients with COVID-19 admitted to specialised healthcare hospitals in the Capital Province of Finland during the first wave of COVID-19 between 27 February and 21 June 2020 were retrospectively studied. We gathered the blood and respiratory tract culture reports of these patients and analysed their association with 90-day case-fatality using multivariable regression analysis. Results A severe bacterial infection was diagnosed in 40/585 (6.8%) patients with COVID-19. The range of bacteria was diverse, and the most common bacterial findings in respiratory samples were gram-negative, and in blood cultures gram-positive bacteria. Patients with severe bacterial infection had longer hospital stay (mean 31; SD 20 days) compared to patients without (mean 9; SD 9 days; p < 0.001). Case-fatality was higher with bacterial infection (15% vs 11%), but the difference was not statistically significant (OR 1.38 CI95% 0.56-3.41). Conclusions Severe bacterial infection complicating COVID-19 was a rare occurrence in our cohort. Our results are in line with the current understanding that antibiotic treatment for hospitalised COVID-19 patients should only be reserved for situations where a bacterial infection is strongly suspected. The ever-evolving landscape of the pandemic and recent advances in immunomodulatory treatment of COVID-19 patients underline the need for continuous vigilance concerning the possibility and frequency of nosocomial bacterial infections. |
| Databáze: | OpenAIRE |
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