Doxorubicin promotes breast cancer cell migration and invasion via DCAF13
| Autor: | Jinkui Yang, Daoyong Zhang, Dongmei Zhou, Zhaoran Sun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Epithelial-Mesenchymal Transition
QH301-705.5 medicine.medical_treatment Triple Negative Breast Neoplasms chemotherapy doxorubicin General Biochemistry Genetics and Molecular Biology Metastasis breast cancer Breast cancer Cell Movement medicine Humans metastasis Doxorubicin Biology (General) skin and connective tissue diseases Receptor Research Articles DCAF13 Chemotherapy business.industry EMT RNA-Binding Proteins Cancer medicine.disease Apoptosis Cancer cell Cancer research business Research Article medicine.drug |
| Zdroj: | FEBS Open Bio, Vol 12, Iss 1, Pp 221-230 (2022) FEBS Open Bio |
| ISSN: | 2211-5463 |
| Popis: | DDB1 and CUL4 associated factor 13 (DCAF13) is a substrate receptor in the CUL4‐DDB1 E3 ligase, and its expression is associated with the prognosis of certain cancers. In the present study, we report evidence that DCAF13 is aberrantly overexpressed in human breast cancer and its expression is positively associated with cancer progression. Further analysis showed that the DCAF13 expression level is significantly higher in triple‐negative breast cancer compared to non‐triple‐negative breast cancer, indicating a positive correlation between its expression and the aggressiveness of breast cancer. Subsequent studies revealed that DCAF13 regulates cancer cell migration, invasion and epithelial–mesenchymal transition in human breast cancer, whereas it has no significant impact on breast cancer cell proliferation, cell cycle progressionor apoptosis. Taken together, our results demonstrate that DCAF13 promotes the epithelial–mesenchymal transition in human breast cancer cells, indicating an involvement in breast cancer metastasis. Furthermore, we report that doxorubicin, a widely used chemotherapy drug, increases DCAF13 expression in breast cancer cells, leading to enhanced cancer cell migration and invasion. These results suggest that doxorubicin chemotherapy may increase the risk of metastasis of drug‐resistant breast cancer cells, and future therapeutics targeting DCAF13 may help reduce the risk, especially for patients undergoing chemotherapy. DCAF13 is a substrate receptor in the CUL4‐DDB1 E3 ligase. We report that doxorubicin, a widely used chemotherapy drug, increases DCAF13 expression in breast cancer cells, leading to enhanced cancer cell migration and invasion, suggesting that doxorubicin may increase the risk of metastasis of drug‐resistant breast cancer cells, and future therapeutics targeting DCAF13 may help reduce the risk. |
| Databáze: | OpenAIRE |
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