Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis
| Autor: | Wen-I Lee, Liang-Shiou Ou, Jing-Long Huang, Chih-Te Charles Wu, Kuo-Wei Yeh |
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| Rok vydání: | 2010 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty animal structures Regulatory T cell Arthritis chemical and pharmacologic phenomena complex mixtures Pathogenesis Rheumatology Predictive Value of Tests Internal medicine Heat shock protein Synovial Fluid medicine Synovial fluid Humans Autoantibodies business.industry fungi Autoantibody General Medicine Chaperonin 60 medicine.disease Prognosis Arthritis Juvenile medicine.anatomical_structure Endocrinology Antirheumatic Agents HSP60 business |
| Zdroj: | Clinical rheumatology. 30(7) |
| ISSN: | 1434-9949 |
| Popis: | Heat shock protein (Hsp) 60 has been implicated in the pathogenesis of various inflammatory and autoimmune diseases. This study aimed to investigate synovial fluid and serum concentrations of Hsp60 and anti-Hsp60 and their relationship with juvenile idiopathic arthritis (JIA). Forty-eight patients with JIA, including 22 oligo-articular, 19 poly-articular, and 7 systemic diseases, and 33 normal controls were enrolled in this study. Synovial fluid and serum Hsp60 and anti-Hsp60 concentrations were measured via ELISA. Serum concentrations of Hsp60 of active and inactive oligo- and poly-articular JIA were significantly higher than those of normal controls. Serum concentration of anti-Hsp60 in active oligo-articular JIA was higher than that of normal controls (49.25 vs. 35.76 ng/mL, p = 0.059). Similarly, serum concentration of anti-Hsp60 in active poly-articular JIA was significantly higher than that of inactive samples (65.05 vs. 26.54 ng/mL, p = 0.008). In addition, serum concentration of Hsp60 correlated with the time required for remission from flare-ups in patients with JIA. Serum concentration of Hsp60 correlated well with time required for remission from flare-ups in patients with JIA, representing a potential disease marker to monitor disease activity. |
| Databáze: | OpenAIRE |
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