The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects
| Autor: | Charles W. Francis, Neil Blumberg, J. J. O'Brien, D. L. Springer, Richard P. Phipps, S. Bancos, Sherry L. Spinelli, G. M. Lehmann, Mark B. Taubman |
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| Rok vydání: | 2008 |
| Předmět: |
Peroxisome proliferator-activated receptor
Inflammation Review Article 030204 cardiovascular system & hematology behavioral disciplines and activities PPAR agonist Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Drug Discovery Medicine Pharmacology (medical) Platelet Platelet activation Receptor lcsh:QH301-705.5 030304 developmental biology chemistry.chemical_classification 0303 health sciences business.industry 3. Good health lcsh:Biology (General) chemistry Hemostasis Immunology Cancer research medicine.symptom business |
| Zdroj: | PPAR Research, Vol 2008 (2008) PPAR Research |
| ISSN: | 1687-4765 1687-4757 |
| DOI: | 10.1155/2008/328172 |
| Popis: | Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation. An emerging body of evidence links platelet function and thrombosis to vascular inflammation. peroxisome proliferator-activated receptors (PPARs) play a major role in modulating inflammation and, interestingly, PPARs (PPARβ/δand PPARγ) were recently identified in platelets. Additionally, PPAR agonists attenuate platelet activation; an important discovery for two reasons. First, activated platelets are formidable antagonists that initiate and prolong a cascade of events that contribute to cardiovascular disease (CVD) progression. Dampening platelet release of proinflammatory mediators, including CD40 ligand (CD40L, CD154), is essential to hinder this cascade. Second, understanding the biologic importance of platelet PPARs and the mechanism(s) by which PPARs regulate platelet activation will be imperative in designing therapeutic strategies lacking the deleterious or unwanted side effects of current treatment options. |
| Databáze: | OpenAIRE |
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