Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study
| Autor: | Kyunglim Koo, Jong Cheol Jeong, Jong Jin Oh, Sejoong Kim, Taeseung Lee, Hyung Sub Park, Seok-Soo Byun, Chang Sik Shin, Dong Wan Chae, Hyoung Won Koh |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Korean Journal of Transplantation. 34:154-166 |
| ISSN: | 2671-8804 2671-8790 |
| DOI: | 10.4285/kjt.2020.34.3.154 |
| Popis: | Background: Kidney transplantation (KT) is regarded as the most effective treatment for end-stage renal disease. The annual number of KT cases in South Korea has in creased rapidly as more centers are implementing a transplantation program. The objective of this study was to determine clinical outcomes of the first 300 consecutive cases of KT in a single center. Methods: Clinical data of 300 cases of KT at Seoul National University Bundang Hos pital from January 2004 to March 2018 were obtained from a prospectively collected database and retrospectively reviewed. Results: The mean age of patients was 47.7±12.9 years, and 59% of patients were male. There were 225 living donors and 75 deceased donors. A total of 42 cases were from ABO-incompatible donors. During a mean follow-up of 68.6±43.5 months, 38 patients (12.7%) experienced rejection. The most common cause was acute T-cell mediat ed rejection (9.0%). Eighteen patients experienced graft loss. One-year and 5-year death-censored graft survival rates were 99% and 96.6%, respectively. One-year and 5-year patient survival rates were 98.3% and 96.6%, respectively. Multivariate analysis revealed that graft weight-to-recipient weight ratio and rejection were significant fac tors affecting graft survival. Conclusions: This single-center review demonstrates clinical outcomes comparable to other major centers. Such good outcomes were obtained by good patient selection, dedicated transplant physicians, and adequate use of immunosuppressive therapy. |
| Databáze: | OpenAIRE |
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