Comparison of prothrombin time tests used in the monitoring of edoxaban and their evaluation as indicators of the reversal effect
| Autor: | Akimichi Ohsaka, Masataka Nagayama, Yoko Tabe, Maiko Yuri, Makoto Hiki, Toshiaki Iba, Mari Emmi, Koichiro Aihara |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.drug_mechanism_of_action
Pyridines Factor Xa Inhibitor 030204 cardiovascular system & hematology Pharmacology Positive correlation Care setting 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Edoxaban medicine Humans 030212 general & internal medicine Reversal effect Prothrombin time Dose-Response Relationship Drug Plasma samples medicine.diagnostic_test Chemistry Hematology Blood Coagulation Factors Thiazoles Prothrombin Time Drug Monitoring PROTHROMBIN COMPLEX Factor Xa Inhibitors |
| Zdroj: | International Journal of Hematology. 103:665-672 |
| ISSN: | 1865-3774 0925-5710 |
| Popis: | Clinical demand for the prompt assessment of the activity of direct-acting factor Xa inhibitors in the emergency care setting is increasing. In the present study, we examined whether prothrombin time (PT) tests can serve as a clinically useful indicator of anti-factor Xa activity. In the first series, the in vitro effect of edoxaban on PT was evaluated by spiking human plasma with edoxaban and measuring PT using three different commercial PT tests. In the second series, the reversal effect of prothrombin complex concentrates (PCC) and activated PCC (aPCC) in edoxaban-spiked plasma was evaluated. In the third series, PT of plasma samples from patients administered either 15 or 30 mg/day of edoxaban was assessed, and the results were compared with edoxaban concentrations determined by a calibrated anti-factor Xa activity assay. The spike test revealed that all PT reagents positively correlated with edoxaban. The sensitivity to edoxaban varied among the three reagents and Triniclot(®) Excel S showed the best performance. Prolonged PT by edoxaban was reversed by PCC and aPCC in a dose-dependent manner; however, complete reversal was not achieved. Positive correlation between anti-factor Xa activity and PT was shown in the clinical samples at the edoxaban range from 0 to >300 ng/mL. |
| Databáze: | OpenAIRE |
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