| Popis: |
EVER since 1905, when Donovan 1 described the peculiar intracellular and extracellular encapsulated organisms which he found in fresh spreads taken from ulcerative lesions of granuloma inguinale, the nature of the Donovan body has excited great interest. Though Donovan himself expressed the opinion that the organism is a protozoan, its position in the field of toxonomy was a moot point, eliciting much labor but little light, until Anderson, DeMonbreun and Goodpasture 2 successfully cultivated the Donovan body in the yolk of chick embryos. According to these investigators the organism is a bacillus, for which they proposed the generic name "Donovania" and the specific name "granulomatis." The therapy of the disease was ineffective until 1913, when intravenous administration of antimony and potassium tartrate was introduced by de Beaurepaire, Aragao and Vianna. 3 This drug was enthusiastically acclaimed by Low and Newham, 4 Pardo, 5 and Randall, Small and Belk. 6 Fraser |
