Immunomodulation by Macrolide Antibiotics
| Autor: | H. Abdelghaffar, M.-T. Labro |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Phagocyte
Neutrophils medicine.medical_treatment Biology Cystic fibrosis Microbiology Immune system medicine Animals Humans Pharmacology (medical) Inflammation Pharmacology Bacterial Infections medicine.disease Cystic fibrosis transmembrane conductance regulator Anti-Bacterial Agents Erythromycin Multiple drug resistance Infectious Diseases medicine.anatomical_structure Cytokine Oncology Cancer cell Immunology biology.protein Diffuse panbronchiolitis |
| Zdroj: | Journal of Chemotherapy. 13:3-8 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.2001.13.1.3 |
| Popis: | Macrolide antibiotics are strongly concentrated within host cells, a property that sustains their activity against intracellular pathogens and is likely responsible for the modulation of cell metabolism and function. There is extensive literature on the subject of macrolide-induced modulation of immune responses. Erythromycin A derivatives seem to display anti-inflammatory activity in vitro, in some animal models and in various clinical settings such as diffuse panbronchiolitis (DPB). The underlying mechanisms are not yet fully understood: inflammatory cytokine and oxidant production by phagocytes is down-regulated by these drugs, but other possible targets include bacterial virulence factors, bronchial and epithelial cells, etc. Also, a link has been suggested between the macrolide transmembrane carrier system and the P-glycoprotein family, which comprises MDR (multiple drug resistance) and CFTR (cystic fibrosis transmembrane conductance regulator), which are respectively involved in the chemotherapeutic resistance of cancer cells and in the genesis of cystic fibrosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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