Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels
| Autor: | Ken-ichi Hirata, Eiji Hiraoka, Chikao Iwai, Yoshitomo Miyamoto, Masakatsu Shimizu, Masayoshi Hashimoto, Yasuaki Matsuda, Hozuka Akita, Mitsuhiro Yokoyama, Tatsuro Ishida, Teishi Kajiya, Kenji Kanazawa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Endothelial lipase
Male medicine.medical_specialty Hypercholesterolemia Myocardial Infarction Single-nucleotide polymorphism Polymorphism Single Nucleotide chemistry.chemical_compound High-density lipoprotein Sex Factors Risk Factors Internal medicine medicine Diabetes Mellitus Humans Myocardial infarction Allele frequency business.industry Cholesterol HDL Case-control study Age Factors General Medicine Odds ratio Lipase Middle Aged medicine.disease Endocrinology chemistry Case-Control Studies Acute Disease Hypertension Multivariate Analysis Female Gene polymorphism Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 71(6) |
| ISSN: | 1346-9843 |
| Popis: | Background Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI). Methods and Results A case - control study of 107 AMI patients and 107 control subjects was conducted. T allele frequency was lower in the AMI group than in controls (0.18 vs 0.26, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|