Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature
| Autor: | G. I. Beerthuizen, Sylvia H. Kardaun, S. van Hattem |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
STEVENS-JOHNSON-SYNDROME medicine.medical_specialty Dermatology Erysipelas Floxacillin Clinical report medicine Humans Drug reaction SPECTRUM business.industry SYSTEMIC SYMPTOMS ADVERSE DRUG-REACTIONS medicine.disease Acute generalized exanthematous pustulosis Toxic epidermal necrolysis Anti-Bacterial Agents PATTERN stomatognathic diseases Acute Generalized Exanthematous Pustulosis Stevens-Johnson Syndrome EUROSCAR Female Flucloxacillin DRESS business medicine.drug |
| Zdroj: | BRITISH JOURNAL OF DERMATOLOGY, 171(6), 1539-1545. Wiley |
| ISSN: | 0007-0963 |
| Popis: | Acute generalized exanthematous pustulosis (AGEP) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse drug reactions. Especially in TEN, large areas of the skin and mucosae may become detached. Although AGEP and SJS/TEN are distinct entities with a different clinical picture, pathogenesis, prognosis and treatment, they may share some features, raising the hypothesis of overlap between both entities. We present a severe case of AGEP, caused by flucloxacillin, clinically presenting with TEN-like features and pronounced systemic symptoms with haemodynamic and respiratory instability. Furthermore, we present a review of the literature on cases of AGEP with features resembling SJS/TEN or a supposed overlap with SJS/TEN. |
| Databáze: | OpenAIRE |
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