Electrocardiographic changes associated with insulin resistance
| Autor: | Marja-Riitta Taskinen, Antti Hakkarainen, Marit Granér, Markku O. Pentikäinen, Nina Lundbom, Reijo Siren, Markku S. Nieminen, Kristofer Nyman, Jesper Lundbom, Kirsi Lauerma |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Magnetic Resonance Spectroscopy Heart disease Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Left ventricular hypertrophy Body Mass Index Electrocardiography QRS complex Insulin resistance Risk Factors Internal medicine Diabetes mellitus medicine Humans Obesity cardiovascular diseases Triglycerides Adiposity Retrospective Studies Metabolic Syndrome Nutrition and Dietetics business.industry Myocardium Cholesterol HDL Fasting Middle Aged medicine.disease Magnetic Resonance Imaging 3. Good health Cross-Sectional Studies Multivariate Analysis Linear Models Cardiology Hypertrophy Left Ventricular Insulin Resistance Waist Circumference Steatosis Metabolic syndrome Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 24:315-320 |
| ISSN: | 0939-4753 |
| Popis: | Cardiac steatosis has been related to increased risk of heart disease. We investigated the association between cardiac steatosis, electrocardiographic (ECG) abnormalities, and individual components of the metabolic syndrome (MetS).A 12-lead ECG and laboratory data were examined in 31 men with the MetS and in 38 men without the MetS. Myocardial triglyceride (MTG) content was measured with 1.5 T magnetic resonance (MR) spectroscopy and epicardial and pericardial fat by MR imaging. MTG content, epicardial and pericardial fat depots were higher in men with the MetS compared with subjects without the MetS (p0.001). The heart rate was increased (p0.001), the PR interval was longer (p0.044), the frontal plane QRS axis shifted to the left (p0.001), and the QRS voltage (p0.001) was lower in subjects with the MetS. The frontal plane QRS axis and the QRS voltage were inversely correlated with MTG content, waist circumference (WC), body mass index (BMI), TGs, and fasting blood glucose. High-density lipoprotein cholesterol correlated positively and measures of insulin resistance negatively with the QRS voltage. MTG content and hypertriglyceridemia were determinants of the frontal plane QRS and WC and hyperglycemia were predictors of the QRS voltage.The MetS and cardiac steatosis appear to associate with multiple changes on 12-lead ECG. The frontal plane QRS axis is shifted to the left and the QRS voltage is lower in subjects with the MetS. Standard ECG criteria may underestimate the presence of left ventricular hypertrophy in obese subjects with cardiometabolic risk factors. |
| Databáze: | OpenAIRE |
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