Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart
| Autor: | Savas Ustunova, Ebru Gürel Gürevin, Elif Ilkay Armutak, Ozden Hatirnaz Ng, Selçuk Takır, Ugur Ozbek, Cihan Demirci Tansel, Nadim Yilmazer, Didem Altindirek, B. Sönmez Uydeş Doğan, Huri Bulut |
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| Přispěvatelé: | Giresun Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı, Takır, Selçuk, İÜC, Veteriner Fakültesi, Veteriner Hekimliği Temel Bilimler Bölümü, Acibadem University Dspace, ÜSTÜNOVA, SAVAŞ, İstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Bulut, Huri |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
H2s Protects Hydrogen sulfide Failure Ischemia Expression Sodium hydrosulfide oxidative damage Pharmacology Hydrogen sulphide ischemia/reperfusion injury General Biochemistry Genetics and Molecular Biology Nitric oxide isolated heart Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine nitric oxide medicine Animals Hydrogen Sulphide Inhibition Ischemia-Reperfusion Injury Cardioprotection biology Chemistry Cystathionine gamma-Lyase Isolated Rat Heart medicine.disease Synthase Cystathionine beta synthase Rats 030220 oncology & carcinogenesis Reperfusion Injury Hypertension biology.protein ÜSTÜNOVA S. TAKIR S. YILMAZER N. Bulut H. ALTINDİREK D. HATIRNAZ NG Ö. Tansel C. D. Dogan B. S. U. ÖZBEK U. ARMUTAK E. İ. et al. -Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart- IN VIVO cilt.34 ss.2507-2516 2020 Ischemia / Reperfusion Injury Reperfusion injury Research Article |
| Zdroj: | In Vivo |
| Popis: | Altindirek, Didem/0000-0001-5068-2968; Armutak, Elif Ilkay/0000-0002-7359-6568 WOS:000574979000007 PubMed ID: 32871779 Background/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfiision (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 mu M) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H2S and NO increase each other's production suggesting their interaction and cooperation in cardioprotection against I/R injury. Scientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [31508, 55736, 47109] This work was supported by Scientific Research Projects Coordination Unit of Istanbul University [grant numbers; 31508, 55736 and 47109]. |
| Databáze: | OpenAIRE |
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