Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
| Autor: | D. Stoeva, N. Marinova, B. Pencheva, G. Michailov, S. Krivoshiev, R. Mihaylov |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030232 urology & nephrology Parathyroid hormone chemistry.chemical_element 030204 cardiovascular system & hematology Calcium urologic and male genital diseases albuminuria End stage renal disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Vitamin D and neurology parathyroid hormone In patient phosphorus end-stage renal disease calcium business.industry Phosphorus vitamin d General Medicine female genital diseases and pregnancy complications Endocrinology chemistry albumin: creatinine ratio in the urine Albuminuria Medicine Hemodialysis medicine.symptom business |
| Zdroj: | Acta Medica Bulgarica, Vol 43, Iss 1, Pp 23-29 (2016) |
| ISSN: | 0324-1750 |
| DOI: | 10.1515/amb-2016-0003 |
| Popis: | Summary Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters and the correlation between them in order to optimize therapy with vitamin D in patients with end-stage renal disease (ESRD) on hemodialysis. In 53 patients on hemodialysis due to ESRD, vitamin D [Calcidiol (25(OH)D], parathyroid hormone (PTH), calcium, phosphorus, albuminuria, albumin:creatinine ratio (ACR) and other parameters have been followed up. Analysis of the levels of vitamin D has been carried out by High Performance Liquid Chromatography (HPLC), the PTH is determined by the system Centaur XP, Siemens Diagnostic, Electro-chemiluminescence immunoassay (ECLIA), and for albumin in urine we used immunological method [Miltigent microalbumin assay (Abbott Laboratories Diagnostics). We found out deficiency and insufficiency of vitamin D in 56.6% and 37.7%, as well as average 4.5 times increase in the PTH, hyperphosphatemia, hypocalcemia, albuminuria (A2 or A3), over 10 times increase in the ACR, secondary hyperparathyroidism. We registered a negative correlation between vitamin D and PTH. We confirmed the increase in creatinine and cystatin C in the patients on hemodialysis. There are few literature data for patients on hemodialysis, however, regarding the extent of the vitamin deficiency and its relationship with PTH, albuminuria, calcium, phosphorus, etc. Our data have indicated that patients on hemodialysis due to ESRD are associated with high incidence of vitamin D insufficiency or deficiency. |
| Databáze: | OpenAIRE |
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