Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?

Autor: Nadine Bernard, Anne-Sophie Mariet, Paul Sagot, Frédéric Mauny, Sophie Pujol, Jérôme Defrance, Didier Riethmuller, Mathieu Boilleaut, Marie Vasseur-Barba, Eric Benzenine, Hélène Houot, Catherine Quantin, Anne-Laure Parmentier, Gérard Thiriez
Přispěvatelé: Service Biostatistiques et Informatique Médicale (CHU de Dijon) (DIM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Dijon Bourgogne, Inserm, Clinical Investigation Center of Dijon (Inserm CIC 1432), Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses (B2PHI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris], Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), CHU besancon - Service de Réanimation Pédiatrique, Néonatalogie et Urgences Pédiatriques, Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Service de gynécologie-obstétrique [CHRU Besançon], Atmo bourgogne Framche-Comté [Besançon], Centre Scientifique et Technique du Bâtiment (CSTB Saint Martin d'Hères), Centre Scientifique et Technique du Bâtiment (CSTB), Théoriser et modéliser pour aménager (UMR 6049) (ThéMA), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de Gynécologie Obstétrique [CHRU Besançon], Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Atmo Bourgogne Franche-Comté [Besançon], Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Université de Franche-Comté (UFC)
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Nitrogen dioxide NO2
Nitrogen Dioxide
Population
Air pollution
010501 environmental sciences
medicine.disease_cause
Logistic regression
01 natural sciences
Fetal Development
03 medical and health sciences
0302 clinical medicine
Pregnancy
Air Pollution
medicine
Humans
030212 general & internal medicine
Cities
education
Maternal-Fetal Exchange
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
lcsh:GE1-350
Air Pollutants
education.field_of_study
Fetus
Fetal Growth Retardation
Obstetrics
business.industry
Multiple pregnancies
Fetal growth restriction
Infant
Newborn
Pregnancy Outcome
[SHS.GEO]Humanities and Social Sciences/Geography
Odds ratio
medicine.disease
Confidence interval
Small for gestational age SGA
Maternal Exposure
Infant
Small for Gestational Age
Small for gestational age
Female
Pregnancy
Multiple
business
Zdroj: Environment International
Environment International, Elsevier, 2018, 121, pp.890-897. ⟨10.1016/j.envint.2018.10.015⟩
Environment International, Vol 121, Iss, Pp 890-897 (2018)
ISSN: 0160-4120
Popis: Background: Multiple pregnancies (where more than one fetus develops simultaneously in the womb) are systematically excluded from studies of the impact of air pollution on pregnancy outcomes. This study aims to analyze, in a population of multiple pregnancies, the relationship between fetal growth restriction (FGR), small for gestational age (SGA) and exposure to air pollution in moderately polluted cities. Methods: All women with multiple pregnancies living in the city of Besançon or in the urban area of Dijon and who delivered at a university hospital between 2005 and 2009 were included. FGR and SGA were obtained from medical records. Outdoor residential nitrogen dioxide (NO2) exposure was assessed using the mother's address, considering a 50 m radius buffer over the following defined pregnancy periods: each trimester, entire pregnancy and two months before delivery. Logistic regression analyses were performed. Results: This study included 249 multiple pregnancies with 506 newborns. The median of NO2 concentration considering a 50 m radius buffer during entire pregnancy was 23.1 μg/m3 (minimum at 10.1 μg/m3 and maximum at 46.7 μg/m3). No association was observed between NO2 and SGA whatever the pregnancy period (the odds ratio (OR) range 0.78 to 0.88). Regarding FGR, the OR associated with an increase of 10 μg/m3 of NO2 exposure during entire pregnancy was 1.52 (95% Confidence Interval (CI): 1.02–2.26). Similar results were observed for NO2 exposure during the various pregnancy periods. Conclusions: These results are in line with an association between NO2 and fetal growth in multiple pregnancies for an exposure mostly below the threshold set out in European legislation. Keywords: Multiple pregnancies, Fetal growth restriction (FGR), Small for gestational age (SGA), Air pollution, Nitrogen dioxide (NO2)
Databáze: OpenAIRE
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