Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation
Autor: | Erika L.F. Holzbaur, C Alexander Boecker |
---|---|
Rok vydání: | 2019 |
Předmět: |
Neurons
0301 basic medicine Extramural Endosome Chemistry General Neuroscience Autophagy Cellular pathways Endosomes Axons Article Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure medicine Compartment (development) Degradation (geology) Soma Lysosomes Neuroscience 030217 neurology & neurosurgery Function (biology) |
Zdroj: | Curr Opin Neurobiol |
ISSN: | 0959-4388 |
DOI: | 10.1016/j.conb.2019.01.005 |
Popis: | Autophagy and endo-lysosomal degradation are two parallel degradation pathways essential for maintaining neuronal health and function. Autophagosomes and endosomes sequester cellular cargo through different mechanisms, but these pathways converge upon fusion with lysosomes. Both pathways are spatially regulated, with distinct features evident in the soma, axons, and dendrites, possibly as an adaptation to the unique morphology of neurons and the specific demands of each compartment. Relatively little is known about how autophagy and endo-lysosomal degradation interact and how their activities may be coordinated. We review our current understanding of autophagy and endo-lysosomal degradation in neurons, highlighting common features and differences as well as the intersection of these two essential cellular pathways. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...