Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex
| Autor: | Debra A. Fleischman, Lei Yu, Robert S. Wilson, David A. Bennett, Philip L. De Jager, Hongyu Zhao, Xiaoqing Yu, Turhan Canli |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Gene Expression Prefrontal Cortex Disease Bioinformatics Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine 5. Gender equality Alzheimer Disease Neoplasms medicine Humans Cognitive Dysfunction Prospective Studies Cognitive decline Social isolation Prospective cohort study Gene lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Aged Memory and aging Aged 80 and over Inflammation business.industry Loneliness 3. Good health Dorsolateral prefrontal cortex Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Social Isolation Female Autopsy medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Translational Psychiatry, Vol 8, Iss 1, Pp 1-9 (2018) Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | Subjective social isolation, loneliness, is associated with poor mental and physical health, but the underlying molecular mechanisms are poorly understood. Here we analyzed loneliness data collected on average 5 years ante-mortem and RNA gene expression at death in postmortem dorsolateral prefrontal cortex (DLPFC) from 181 participants in the Rush Memory and Aging Project (MAP), a longitudinal, prospective cohort study of common chronic conditions of aging. Our analytic protocol controlled for biographical variables (age, sex, education), psychological and health variables (depressive symptoms, interval between assessment and autopsy, slope of cognitive decline, AD pathology, presence of infarcts) and RNA integrity. Our results are based on a pre-ranked Gene Set Enrichment Analysis (GSEA) at FDR-corrected q-values |
| Databáze: | OpenAIRE |
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